聚合物胶束在经皮给药系统中的应用  

Application of Polymeric Micelles in Transdermal Drug Delivery Systems

作　　者：孙媛媛[1,2] 陈博[1,2,3] 邵兵[1] 孙玉阳[1,2,3] 张爽[2] 洪洋[2] 王艺凝[2] 陈悦[2] 吴琳华[1,2,3] 纪宏宇[1,2,3] 

机构地区：[1]哈尔滨医科大学附属第二医院药学部,哈尔滨150086 [2]哈尔滨医科大学药学院 [3]黑龙江省高校重点实验室

出　　处：《中国药师》2017年第5期904-906,共3页China Pharmacist

基　　金：黑龙江省大学生创新创业训练计划项目(编号:1022620152422)

摘　　要：目的:综述聚合物胶束作为药物载体在经皮传递系统中的应用进展。方法:根据国内外发表的最新文献,对聚合物胶束的制备方法、促进皮肤渗透的机制、释药过程及其在经皮给药系统中的应用进行分析与讨论。结果:聚合物胶束具有增加难溶性药物的溶解度,促进药物的经皮吸收等作用,作为药物载体在经皮传递系统的应用越来越广泛。结论:聚合物胶束可作为药物载体被广泛用于经皮给药系统的研究中,具有较好的发展前景。Objective： To review the application of polymeric micelles as the vehicles in transdermal delivery systems. Methods： Based on the recently published papers, the researches of preparation, penetration mechanism, drug release and application of polymeric micelles in transdermal delivery systems were classified and summarized. Results： Polymeric micelles were extensively applied as drug vehicles due to the ability of solubihzation and transdermal absorption enhancement. Conclusion： Polymeric mieelles can be used as promising vehicles in transdermal delivery systems, which show a good application prospect.

关 键 词：聚合物胶束 制备 促渗机制 释药 经皮给药系统 

分 类 号：R944.9[医药卫生—药剂学]