黄麦合剂中淫羊藿苷、二苯乙烯苷、金丝桃苷的稳定性考察  

Stability of Icariin,2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-D-glucoside and Hyperoside in Huangmai Mixture

作　　者：林君 姚晓东[2] 夏玲红[2] 金冠钦[2] 

机构地区：[1]上海方心健康科技发展股份有限公司,上海200032 [2]上海交通大学医学院附属仁济医院临床药理实验室

出　　处：《中国药师》2017年第5期916-920,共5页China Pharmacist

基　　金：上海浦东新区科技局中医药技术创新体系项目(编号:PKM2010-13);上海市科学技术委员会科技支撑项目(编号:12401900502)

摘　　要：目的:考察黄麦合剂中淫羊藿苷、二苯乙烯苷、金丝桃苷的稳定性。方法:以黄芪甲苷、巴戟天药材的TLC鉴别试验,以及淫羊藿苷、二苯乙烯苷、金丝桃苷的HPLC色谱法含量测定为指标,考察黄麦合剂在加速试验及长期试验条件下的稳定性。结果:在加速试验及长期试验条件下,黄芪甲苷、巴戟天药材以及淫羊藿苷具有良好的稳定性;二苯乙烯苷、金丝桃苷在加速试验、长期试验条件下稳定性差。结论:黄麦合剂各成分中二苯乙烯苷、金丝桃苷稳定性不佳,应尝试改造成固体剂型,以保证稳定性。Objective： To investigate the stability of icariin, 2,3,5,4＇-tetrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside in Huangmai mixture. Methods： TLC was used to identify astrogaloside IV and Morindae officinalis Radix, and HPLC was used to determine the contents of icariin, 2,3,5,4＇ -retrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside. The stability of Huangmai mixture under the conditions of accelerated testing and long-term testing was assessed. Results： Astrogaloside IV, Morindae officinalis Radix and icariin showed good stability during the accelerated testing and long-term testing. The contents of 2,3,5,4＇ -tetrahydroxy-stilbene- 2-O-β-D-glucoside and hyperoside declined quickly during the stability testing. Conclusion： Hyperoside and 2,3,5,4＇ -retrahydroxystilbene-2-O-β-D-glueoside are unstable in Huangrnai mixture. A novel solid dosage form of Huangmai should be developed to obtain better stability.

关 键 词：黄麦合剂 黄芪甲苷 巴戟天 淫羊藿苷 二苯乙烯苷 金丝桃苷 加速稳定性 长期稳定性 中药复方 

分 类 号：R942[医药卫生—药剂学]