1,3-二羟基异丙氧基-琥珀酸-8-莪术醇酯纳米混悬剂的制备及其性能研究  

Preparation of 1,3-dihydroxyisopropoxy-succinic acid-8-curcumol ester nanosuspensions and its properties

作　　者：王义[1,2] 王文倩[3] 尹萌[1] 孙忠浩 张泉洋 田瑜[2] 许旭东[2] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,黑龙江哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,北京100193 [3]天津药物研究院,天津300193

出　　处：《现代药物与临床》2017年第4期579-583,共5页Drugs & Clinic

基　　金：国家自然科学基金资助项目(81302656);中国医学科学院医学与健康科技创新工程经费资助项目(2016-I2M-1-012)

摘　　要：目的制备1,3-二羟基异丙氧基-琥珀酸-8-莪术醇酯纳米混悬剂(Cur-p-NS),并考察其一般特性、载药量和体外释放特性。方法采用超声–溶剂沉淀法制备Cur-p-NS,考察其粒度大小,多聚分散系数和Zeta电位。结果 Cur-p-NS的平均粒径为162.60±2.12 nm,多分散系数为0.182±0.002,Zeta电位为-24.60±8.97 m V,平均载药量为0.942 mg/mg,累积释放率可达到77%。结论 Cur-p-NS制备工艺简单和效果好,具有持续释放的特性。Objective To prepare 1, 3-dihydroxyisopropoxy-succinic acid-8-curcumol ester nanosuspensions （Cur-p-NS） and study their general characteristics, drug loading, and drug release characteristicsin vitro.Methods Cur-p-NS was prepared by ultrasonic- solvent precipitation. And the particle size, polydispersion index, and Zeta potential of the nanosuspension were studied.Results The particle size, polydispersion index, Zeta potential ,the drug-loading content, and the cumulative release rate of the nanosuspension were 162.60 ＆#177; 2.12 nm, 0.182 ＆#177; 0.002,？24.60 ＆#177; 8.97 mV, 0.942 mg/mg, and 77%, respectively.Conclusion Cur-p-NS has simple preparation and good effect, which has characteristic of sustained release.

关 键 词：1 3-二羟基异丙氧基-琥珀酸-8-莪术醇酯 纳米混悬剂 溶剂沉淀法 粒径 体外释放特性 1 

分 类 号：R944[医药卫生—药剂学]