The genome-wide molecular regulation of mouse gastrulation embryo  

作　　者：Guangdun Peng Naihe Jing 

机构地区：[1]State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences

出　　处：《Science China(Life Sciences)》2017年第4期363-369,共7页中国科学（生命科学英文版）

基　　金：supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (XDA01010201);National Key Basic Research and Development Program of China (2014CB964804, 2015CB964500);National Natural Science Foundation of China (31430058, 31571513, 31630043, 91519314)

摘　　要：The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region-and population-specific genetic activity underpinning this fundamental developmental process. In this review, we outline the recent progress and the future directions in studies of genome activity for the regulation of mouse embryogenesis at gastrulation.The diverse morphologies among vertebrate species stems from the evolution of a basic body plan that is constituted by a spatially organized ensemble of tissue lineage progenitors. At gastrulation, this body plan is established through a coordinated morphogenetic process and the delineation of tissue lineages that are driven by the activity of the genome. To explore the molecular mechanisms, in a comprehensive context, it is imperative to glean an understanding of the region-and population-specific genetic activity underpinning this fundamental developmental process. In this review, we outline the recent progress and the future directions in studies of genome activity for the regulation of mouse embryogenesis at gastrulation.

关 键 词：embryo morphogenetic spatially vertebrate diverse fertilization coordinated streak organized ensemble 

分 类 号：Q954.4[生物学—动物学]