关于检验抗病毒药物有效性样本量的比较  

Size Comparison of the Samples for Testing Antiviral Drugs' Effectiveness

作　　者：张峰硕[1] 周平[1] Zhang Fengshuo Zhou Ping(School of Mathematical Sciences, University of Electronic Science and Technology of China, Chengdu 611731, China)

机构地区：[1]电子科技大学数学科学学院,成都611731

出　　处：《统计与决策》2017年第9期31-34,共4页Statistics & Decision

基　　金：国家自然科学基金资助项目(71271042;71501025);中国博士后科学基金资助项目(2015M572467);四川省应用基础计划项目(2016JY0257)

摘　　要：文章基于链式二项式模型,运用符号秩和检验法,将检验抗病毒药物的有效性及所需样本容量与Alexander-Govern检验进行了比较研究,并分析了抗病毒药物的不同控制策略对检验抗病毒药物有效性所需样本容量的影响。研究表明,符号秩和检验所需样本量比becker和wang所用的Alexander-Govern检验所需样本量更少,并且采用治疗加预防策略且尽早发放药物可有效减少样本容量。Based on the Chain binomial model, this paper, by using signed rank-sum test, compares the effectiveness of antiviral drugs and the sample size with Alexander-Govern test. The paper also explores the impact that different control measures produce upon the samples size needed to test the effectiveness of antiviral drugs. The results show that the signed rank-sum test needs even smaller sample size than Alexander-Govern test that becket and wang have used, and that the strategy of treatment with prevention and distributing antiviral drugs as soon as possible help reduce the sample size significantly.

关 键 词：抗病毒药物 符号秩和检验 Alexander-Govern检验 样本容量 

分 类 号：O212.6[理学—概率论与数理统计]