钾通道开放剂对大鼠碘乙酸钠所致骨关节炎疼痛作用的实验观察  

Antinociceptive efficacy of QO-58 in the monosodium lodoacetate rat model for osteoarthritis pain

作　　者：杜明泽[1] 段然[1] 邵德成[2] 张晓阳[2] 张凡[1] 李晗[2] 

机构地区：[1]河北医科大学生物化学与分子生物学教研室神经与血管省部共建重点实验室,石家庄050017 [2]河北医科大学第三医院骨科河北省骨科生物力学重点实验室

出　　处：《中华医学杂志》2017年第17期1333-1336,共4页National Medical Journal of China

基　　金：国家自然科学基金青年基金（81501911）;河北省卫计委青年基金（20150268）

摘　　要：目的观察钾通道开放剂（QO-58）对大鼠碘乙酸钠所致骨关节炎疼痛的影响。方法大鼠右侧膝关节腔内单次注入3mg／50山碘乙酸钠建立骨关节炎疼痛模型，模型成功后腹腔注射给予化合物50mg／kgQO-58，观察其单次给药以及多次给药对大鼠骨关节炎疼痛模型机械刺痛和辐射热痛痛阈的影响。结果单次腹腔注射给予化合物QO-58，于6h和10h显著提高大鼠骨关节炎疼痛模型机械刺痛和辐射热痛痛阈。从第10-14天每天1次腹腔注射给予化合物QO-58，显著提高第12、14天大鼠骨关节炎疼痛模型机械刺痛和辐射热痛痛阈。结论化合物QO-58能够有效缓解碘乙酸钠所致大鼠骨关节炎疼痛。Objective To determine the effects of QO-58 on pain behavior associated with monosodium iodoacetate （MIA）-induced OA. Methods The OA model was established with an intra- articular injection of 3 mg/50 MIA through the right patellar ligament. Then the model rats were treated with 50 mg/kg QO-58 by intraperitoneal injection, and pain-related behaviors were assessed by single administration and multiple administrations of QO-58. Results Single adminstration of QO-58 increased the mechanical threshold and prolonged the withdrawal latency of OA pain with the antinociceptive effect occurring at 6 h and 10 h. Compound QO-58 was administered intraperitoneally once a day from day 10 to 14. Q0-58 significantly increased the mechanical threshold and prolonged the withdrawal latency of OA rats at 12 and 14 days. Conclusion QO-58 showed antinociceptive effects for OA pain in the MIA model after pain development. QO-58 may be an alternative therapeutic treatment for OA.

关 键 词：骨关节炎 乙酸钠 疼痛 QO-58 

分 类 号：R684.3[医药卫生—骨科学]