健孕妇血n清维生素D水平与血脂相关性研究  

Study on the Relationship between Serum Vitamin D level and Blood Cholesterol in Healthy Preg-nant Women

作　　者：田伊茗[1] 吴冬梅[1] 高国芹[1] 马宁[1] 朱东林[1] 刘悦[1] 陆强[1] 

机构地区：[1]河北省秦皇岛市第一医院,河北秦皇岛066000

出　　处：《医学临床研究》2017年第4期625-627,共3页Journal of Clinical Research

基　　金：河北省科学技术研究与发展计划项目（项目编号：132777262）

摘　　要：【目的】探讨妊娠24-28周的健康孕妇维生素D水平与血脂的相关性。【方法】选取2012年5月至2013年8月期间秦皇岛市第一医院产科门诊就诊的91例妊娠24～28周的健康孕妇为观察组，同时选取同时期于本院体检中心就诊的63例健康非妊娠女性为对照组。收集所有受试者姓名、年龄、身高、体重、孕周，测定25羟维生素DEB5（OH）D]浓度、三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）等临床资料，比较两组研究对象一般资料及血清指标比较，并对血清25（OH）D水平与血脂相关性进行分析。【结果】观察组与对照组的年龄分布比较，差异无统计学意义（P〉0．05）；观察组BMI明显高于对照组（P〈0．001）。观察组血清25（OH）D水平显著低于对照组，差异具有统计学意义（P〈0．001）；观察组血清TG、TC、HDL-C、LDL_C水平显著高于对照组，差异均具有统计学意义（均P〈O．05）。观察组25（0H）D水平与TC（r=-0．397，P=0．039〈0．05）、LDL-C（r=-O．301，P=0．041〈0．05）呈显著负相关，与年龄、BMI、TG、HDL-C均无显著相关性（均P〉0．05）。【结论】孕中期健康孕妇25（OH）D水平与血脂显著相关。[Objective]To evaluate the relationship between serum vitamin D level and blood cholesterol in healthy pregnant women at 24-28 weeks of gestation.[Methods]Ninety-one healthy pregnant women with 24-28 weeks gestation were enrolled as the experimental group, and sixty-three non-gestational healthy women were re- cruited as the control group. All cases were from our hospital from May 2012 to August 2013. General information （name, age, height, weight, gestational weeks） and clinical data （triglyceride/TG, low-density lipoprotein cho- lesterol/LDL-C, high-density lipoprotein cholesterol/HDL-C, total cholesterol/TC and serum vitamin D [-25 （OH） D] levels were collected, and the relation between blood cholesterol and serum vitamin D was analyzed.IRe- suits]There was no significant difference between the experimental group and the control group （ P 〉0.05）. The BMI of the experimental group was significantly higher than that of the control group （ P 〈0.001）. The level of serum 25 （OH） D in the experimental group was significantly lower than that in the control group （ P〈0.001）, while levels of serum TG, TC, HDL-C and LDL-C were significantly higher than those in the control group （ P〈 0.05）. The level of 25 （OH） D in the experimental group was significantly negatively correlated with TC （ r = -0.397,P =0.039） and LDL-C （ r = -0.301,P =0.041）. However, it did not show significant correlation with age, BMI, TG, and HDL-C （ P〉0.05）.[Conclusion]Serum vitamin D level is significantly related to the blood cholesterol in women at middle gestational period.

关 键 词：孕妇 维生素D/血液 三乙酰甘油酯 胆固醇 

分 类 号：R714.1[医药卫生—妇产科学]