骨骼肌细胞外基质重塑与胰岛素抵抗的研究进展  

Remodeling of Skeletal Muscle Extracellular Matrix and Insulin Resistance(review)

作　　者：杨亚南[1] 吕君君[1] 王柯[1] 刘冬梅[1] 

机构地区：[1]上海体育学院运动科学学院,上海市200438

出　　处：《中国康复理论与实践》2017年第4期398-401,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金项目(No.31470060);上海体育学院研究生教育创新基金项目(No.yjscx2015070)

摘　　要：骨骼肌细胞外基质(ECM)是肌细胞生存和活动的微环境,其组成成分和结构直接影响肌细胞的活动和功能。在胰岛素抵抗的病理过程中,骨骼肌ECM发生病理性重塑,如胶原蛋白沉积、透明质酸增多、ECM膜蛋白整合素信号通路激活、基质金属蛋白酶和基质金属蛋白酶抑制剂平衡失调。这些病理性变化都会导致胰岛素敏感性下降。Skeletal muscle extracellular matrix（ECM） is the microenvironment for muscle cells to survive and function. Changes in ECM components and structure directly affect the activity and function of muscle cells. Pathological remodeling occurs to skeletal muscle ECM in insulin resistance, including collagen deposition, hyaluronan accumulation, activation of membrane protein integrin signaling pathway, and the imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases, while all those would impair the tissue insulin sensitivity.

关 键 词：胰岛素抵抗 细胞外基质 骨骼肌 纤维化 整合素 综述 

分 类 号：R587[医药卫生—内分泌]