选择性β_1受体阻滞剂对高血压患者运动耐力的影响  

Effect of Selective beta-1 Adrenoreceptor Blocker on Exercise Tolerance in Patients with Hypertention

作　　者：李寿霖[1,2] 张焱[1,2] 刘杰[1,2] 杨威[1,2] 刘立君[1,2] 郑志昌[1,2] 林伟[1,2] 王晓荣[1,2] 王国栋[1,2] 封丽红[1,2] 陈思远[1,2] 杨祖福[1,3] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院心血管内科,北京市100068 [3]中国康复研究中心北京博爱医院心血管内科中医康复科,北京市100068

出　　处：《中国康复理论与实践》2017年第4期446-448,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(No.2015CZ-40)

摘　　要：目的探讨选择性β_1受体阻滞剂对高血压患者运动耐力的影响。方法 2015年5月至2016年5月,72例高血压患者按照是否服用选择性β_1受体阻滞剂分为两组。A组(n=35)行心肺运动试验前2周服用选择性β_1受体阻滞剂,B组(n=37)行心肺运动试验前2周未曾服用任何β受体阻滞剂。两组均行心肺运动试验,比较两组间运动耐力。结果 A组最大收缩压、峰值心率、运动后1 min时心率(HR1)和最大心率血压乘积均低于B组(t>2.012,P<0.05),而HR1恢复值高于B组(t=2.100,P<0.05)。两组间峰值功率及峰值摄氧量均无显著性差异(t<0.689,P>0.05)。结论选择性β_1受体阻滞剂可降低心肌耗氧量,改善迷走神经张力,并未降低高血压患者的运动耐力。Objective To explore the effect of selective beta- 1 adrenoreceptor blocker on exercise tolerance in patients with hyperten- sion. Methods From May, 2015 to May, 2016, 72 patients with hypertension were divided into two groups, according to whether taking the selective beta- 1 receptor blocker. Group A （n=35） took the selective beta- 1 receptor blocker two weeks before cardiopulmonary exercise, while group B （n=37） did not take anything at the same time. The exercise tolerance was compared between two groups. Results The maxi- mal systolic blood pressure, peak heart rate, one-minute heart rate after exercise （HR 1） and rate-pressure product were lower in group A than in group B （t〉2.012, P〈0.05）, however, the recovery value of HR1 was higher in group A than in group B （t=2.100, P〈0.05）. There was no difference in both peak power and peak oxygen uptake between two groups （t〈0.689,P0.05）. Conclusion The selective beta- 1 adrenore- ceptor blocker could reduce myocardial oxygen consumption, and improve vagus nerve activity, but did not reduce exercise tolerance in pa- tients with hypertension.

关 键 词：高血压病 Β1受体阻滞剂 心肺运动试验 

分 类 号：R544.1[医药卫生—心血管疾病]