外周血血小板/淋巴细胞比值与胆道系统肿瘤预后的相关性  

Relationship of Peripheral Blood Platelet to Lymphocyte Ratio with Clinicopathological Features and Prognosis of Biliary Tract Cancer

作　　者：郭雪芬[1] 王若雨[1] 李贺明[1] 赵彤[1] 冀学宁[1] 梁珊珊[1] 王喆[1] 杨玉龙[1] 尹家俊[1] GUO Xue-fen WANG Ruo-yu LI He-ruing et al(Zhongshan Hospital of Dalian University, Dalian 116001, China)

机构地区：[1]大连大学附属中山医院,辽宁大连116001

出　　处：《肿瘤学杂志》2017年第4期300-304,共5页Journal of Chinese Oncology

基　　金：国家自然科学基金资助项目(81502124)

摘　　要：[目的]探讨外周血血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR)与胆道系统恶性肿瘤临床病理特征的相关性及其对预后的影响。[方法]系统回顾126例胆道系统肿瘤患者的临床病理资料,PLR分组根据格拉斯哥预后评分(The Glasgow Prognostic Score,GPS)中对PLR定义的界值,将PLR分为低PLR组(PLR<150)和高PLR组(PLR≥150)。分析PLR水平与胆道系统肿瘤患者临床病理因素的相关性;通过单因素、多因素分析探讨PLR与胆道系统肿瘤预后的相关性。[结果]高PLR组胆道系统肿瘤患者的总生存期(overall survival,OS)与无进展生存期(progression-free survival,PFS)均低于低PLR组,但差异均无统计学意义(P>0.05);单因素分析结果显示纤维蛋白原(Fibrinogen,FG)与胆道系统肿瘤患者的OS和PFS的均有相关性(P<0.05);年龄、PS评分及中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)与PFS有相关性(P<0.05);肿瘤部位、TNM分期与OS有相关性(P<0.05)。多因素分析结果表明年龄、FG是胆道系统肿瘤预后的独立危险因素。分层分析结果显示,不同年龄分组中,PLR与OS和PFS均无相关性(P>0.05)。[结论]目前样本分析结果表明PLR不能作为胆道系统肿瘤预后的一个指标,但仍需继续扩大样本量进一步证实。[Objective] To investigate the association of peripheral platelet to lymphocyte ratio（PLR） with clinicopathological features and prognosis of biliary tract cancer. [Methods] Data of126 patients with biliary tract cancer were retrospectively evaluated. According to the definition of PLR in Glasgow Prognostic Score（GPS）,patients were divided into low PLR group（PLR 〈150） and high PLR group（PLR≥150）. The correlation of PLR with clinicopathological features and prognosis of biliary cancer was analyzed by using univariate and multivariate analyses. [Results] There were no significant differences in overall survival（OS） and progression-free survival（PFS） between high PLR group and low PLR group（P〉0.05）. Univariate analysis showed that fibrinogen（FG） was correlated with OS and PFS in biliary tract cancer patients（P〈0.05）;the age,PS score and neutrophil-to-lymphocyte ratio（NLR） were statistically correlated with PFS（P〈0.05）;the tumor site,TNM stage were statistically correlated with OS（P〈0.05）. Multivariate analysis showed that age and FG were independent risk factors for biliary tract cancer prognosis. [Conclusion] The present study indicates that PLR may not serve as a predicator for prognosis of biliary tract cancer.

关 键 词：血小板/淋巴细胞比值 胆道系统肿瘤 预后 

分 类 号：R735.8[医药卫生—肿瘤]