药物代谢组学研究进展  

Research Progress in Pharmacometabolomics

作　　者：葛纯[1] 曹蓓[2] 冯冬[1] 阿基业[1] 王广基[1] GE Chun CAO Bci FENG Dong A Jiye WANG Guangji(Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China Phase I Clinical Research Lab, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University, Medical School. Nanjing 210008, China)

机构地区：[1]中国药科大学药物代谢动力学重点实验室,江苏南京210009 [2]南京大学医学院附属鼓楼医院Ⅰ期临床试验研究室,江苏南京210008

出　　处：《药学进展》2017年第4期245-253,共9页Progress in Pharmaceutical Sciences

基　　金：国家重大新药创制专项(No.2015ZX09501001);国家自然科学基金(No.81573495;81503139);江苏省临床诊疗技术攻关项目(No.BL2014070)

摘　　要：药物代谢组学通过分析比较药物干预前、后生物体代谢谱,评价和预测药物的疗效、毒性及药动学特征,为临床个体化用药和精准治疗提供了新的思路与策略。从药物代谢组学的应用及其所呈现出的优势与面临的挑战和对策等方面,对目前药物代谢组学研究进展作一综述。Phannacometabolomics aims to estimate and predict the efficacies, toxicities and pharmacokinetics of drugs by analyzing and comparing the metabolic spectra before and after drug interventions, providing new thoughts and strategies for clinical individualized medication and precise treatment. In this paper, the current research progress in pharmacometabolomics was reviewed from the aspects of applications, superiorities, challenges to confront and countermeasures.

关 键 词：药物代谢组学 药物毒性 药效 药动学 个体差异 

分 类 号：R96[医药卫生—药理学]