以油酸为油相的空白O/W微乳体系研究  

Oil-in-water Microemulsion with Oleic Acid as the Oil Phase

作　　者：李玉琴[1,2] 马娟[3] 

机构地区：[1]南通大学药学院,江苏南通226001 [2]中国医药工业研究总院,上海201203 [3]复旦大学药学院,上海201203

出　　处：《中国现代应用药学》2017年第4期549-552,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：南通大学自然科学项目(11Z008)

摘　　要：目的研究以油酸为油相的不同组成微乳体系的相行为特点,考察常见乳化剂和助乳化剂增溶特性,获得水增溶及油酸增溶量均较大的O/W微乳体系。方法采用伪三元相图法,以微乳区域面积(AT)、最大增溶水量(Wm)及对应的乳化剂用量(Sm)为水增溶参数,O/W结构能容纳的最大油酸量(Om)为油酸增溶参数,通过比较筛选出最适乳化剂、助乳化剂及两者质量比,并通过体系电导率随含水量变化及相转变点绘出O/W微乳区域。结果多元醇为助乳化剂时水增溶量有限且易形成凝胶;吐温类乳化剂中吐温20水增溶量最大,吐温80油酸增溶量最大,其油水增溶量与HLB值并不完全成正比;选用吐温80/无水乙醇为混合乳化剂,随着吐温80比例下降,最大油酸增溶量逐步下降,水增溶量先上升再下降,两者比例在1∶1时,所绘制三元相图的微乳区域面积最大,但形成的O/W微乳区域亦有限。结论以油酸为油相,可采用质量比1∶1的吐温80/无水乙醇为混合乳化剂,其水增溶和油酸增溶量均较大,可形成一定区域的O/W微乳。OBJECTIVE To investigate the phase behavior of microemulsion, frequently-used emulsifier and co-emulsifier＇s solubilization ability with oleic acid as the oil phase and find the best quaternary system for water solubilization and oleic acid solubilization. METHODS Pseudo-ternary phase diagrams were constructed to screen the emulsifier, co-emulsifier and mass ratio for both by water solubilization parameters （Av, Win, Sin） and oleic acid solubilization parameter （Om）. O/W microemulsion area in phase diagram was determined by conductivity and phase inversion point. RESULTS The pseudo-ternary system was apt to form gels and the amount of water solubilization was limited with polyalcohol as co-emulsifier. Tween 20 had the maximum amount of water solubilization, but tween 80 had the best Ore; the amount of oil/water solubilization was partly related to the HLB value. When using tween 80/absolute alcohol as mix-emulsifier, Om was in direct to their mass ratio, but water solubilization was not completely; the biggest AT was in 1 ： 1 mass ratio, but the O/W microemulsion area was limited. CONCLUSION The quarternary system of olelic acid, water and tween 80/ethanol with a mass ratio equal to 1 ： 1, has a clear O/W structure and proper amount in water and oleic acid solubilization.

关 键 词：油酸 微乳 相行为 电导率 

分 类 号：R944.9[医药卫生—药剂学]