血浆肿瘤坏死因子-α与超敏C反应蛋白水平在老年急性心肌梗死诊断及治疗中的临床价值分析  

Analysis of clinical value by plasma tumor necrosis factor-α and high sensitivity C-reactive protein in diagnosis and treatment of senile acute myocardial infarction

作　　者：张春煜 陈慧君 安秋花 ZHANG Chun-yu CHEN Hui-jun AN Qiu- hua.(Department of lnternal Medicine, Liaohe Oil field General Hospital, Panjin 124010, China)

机构地区：[1]辽河油田总医院内科,124010

出　　处：《中国实用医药》2017年第9期34-36,共3页China Practical Medicine

摘　　要：目的分析对老年急性心肌梗死(AMI)患者进行血浆肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)检测的临床诊断价值及对治疗的临床价值。方法 80例老年AMI患者作为观察组,80例体检健康人员作为对照组。采集两组受检者的晨起空腹静脉血液标本进行血浆hs-CRP、TNF-α水平检测,观察不同时段观察组患者血浆hs-CRP、TNF-α水平与对照组的差异,以及观察组治疗后不同疗效患者的血浆hs-CRP、TNF-α水平差异。结果观察组患者入院时及入院后第1天、5天、10天血浆hs-CRP、TNF-α水平与对照组比较,差异具有统计学意义(P<0.05);治疗结束后观察组患者的血浆hs-CRP水平为(0.62±0.22)μg/ml、TNF-α水平为(21.02±8.58)pg/ml,与对照组的(0.58±0.19)μg/ml、(19.99±7.86)pg/ml比较差异无统计学意义(P>0.05)。观察组疗效越好的患者血浆hs-CRP、TNF-α水平下降幅度越大,差异有统计学意义(P<0.05)。结论血浆hs-CRP、TNF-α是炎性反应的特异性指标,对老年AMI患者早期诊断及治疗效果评估中具有参考价值。Objective To analyze clinical value by plasma tumor necrosis factor-α（TNF-α） and high sensitivity C-reactive protein（hs-CRP） in diagnosis and treatment of senile acute myocardial infarction（AMI）. Methods There were 80 senile AMI patients as observation group and 80 health people as control group. Morning fasting venous blood samples were taken from the two groups to detect plasma hs-CRP and TNF-α levels. Observation was made on difference of plasma hs-CRP and TNF-α levels between the observation group and the control group at various time points, as well as difference of plasma hs-CRP and TNF-α levels in patients with various curative effects in the observation group. Results The difference of plasma hs-CRP and TNF-α levels at admission and in 1, 5, 10 d after admission between the observation group and the control group had statistical significance（P〈0.05）. After treatment, the observation group had plasma hs-CRP level as（0.62±0.22） μg/ml and TNF-α level as（21.02±8.58） pg/ml. Comparing with（0.58±0.19） μg/ml and（19.99±7.86） pg/ml in the control group, their difference had no statistical significance（P〉0.05）. In the observation group, better curative effect in patients led to larger descend range of plasma hs-CRP and TNF-α levels, and the difference had statistical significance（P〈0.05）. Conclusion As specific indexes in inflammatory reaction, plasma hs-CRP and TNF-α contains reference value for early diagnosis, treatment and curative effect evaluation in senile AMI patients.

关 键 词：急性心肌梗死 肿瘤坏死因子-Α 超敏C反应蛋白 血浆 诊断价值 

分 类 号：R542.22[医药卫生—心血管疾病]