复发性流产的免疫学病因研究进展  

Research progress on immunological etiology of recurrent abortion

作　　者：王爱娟[1] 孙振高[1,2] 张兴兴[1] 宋景艳 王晓明[1] 杨毅[1] 徐凯月 WANG Ai-juan SUN Zheng-gao ZHANG Xin-xin et al(Shandong Chinese Traditional Medicical and Medcine Univercity, Clinical College, 250014 Affilical Hospital, 250014)

机构地区：[1]山东中医药大学临床学院,济南250014 [2]山东中医药大学附属医院,济南250014

出　　处：《中国优生与遗传杂志》2017年第4期1-4,共4页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金(81373676;81674018);山东省科技发展计划项目(2014GSF119021)

摘　　要：复发性流产(recurrent spontaneous abortion,RSA)一般指与同一配偶发生连续3次或3次以上的自然流产。RSA的病因复杂,胚胎作为同种异体移植物不被母体免疫排斥是妊娠建立和维持的关键。近年来对RSA发病与免疫功能异常的关系进行了广泛从基础到临床的研究,本文针对RSA的免疫学病因从自身免疫异常型与同种免疫异常型两大方面进行综述。In terms of immunity,the fetus and its appendages are not rejected by the mother and can develop in the womb,which must depend on the immune tolerance of the mother to the fetus.Once the immune tolerance mechanism can not be formed or destroyed will lead to the occurrence of abortion. According to the pathogenesis of RSA,the pathogenesis of is divided into two categories：autoimmune abnormal type and the same type of abnormal immune system.In this paper,the research progress of immunological etiology of recurrent spontaneous abortion（RSA）were reviewed from two aspects：autoimmune abnormal type and the abnormal type.

关 键 词：复发性流产 自身免疫 同种免疫 器官特异性抗体 非器官特异性抗体 辅助性T细胞 NK细胞 

分 类 号：R714.21[医药卫生—妇产科学]