无抽搐电休克联合利培酮治疗精神分裂症的疗效及对血清泌乳素、认知功能的影响  

Observation on Efficacy of Modified Electroconvulsive Therapy Combined with Risperidone in Treatment of Schizophrenia and Effects on Serum Prolactin and Cognitive Function

作　　者：文启琴[1] 郭伟坚[1] 符卫仙[1] 黄园园[1] 

机构地区：[1]广州医科大学附属脑科医院/广州市惠爱医院精神科,广东广州510370

出　　处：《中国医院用药评价与分析》2017年第3期358-360,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨无抽搐电休克联合利培酮治疗精神分裂症的临床疗效及对患者血清泌乳素、认知功能的影响。方法:选取2015年1月—2016年6月广州医科大学附属脑科医院/广州市惠爱医院收治的精神分裂症患者82例作为研究对象,以随机数字表法分为观察组和对照组,每组41例。对照组患者给予利培酮,观察组患者在对照组基础上加用无抽搐电休克治疗,两组患者均以8周为1个疗程。结果:观察组患者的总有效率明显高于对照组,差异有统计学意义(P<0.05)。治疗8周后,观察组患者阳性症状评分、阴性症状评分明显低于对照组,血清泌乳素水平明显高于对照组,图形自由回忆、人像特点回忆、联想学习、无意义图形再认及指向记忆评分明显高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率的差异无统计学意义(P>0.05)。结论:无抽搐电休克联合利培酮治疗精神分裂症的疗效显著,对血清泌乳素的影响较小,可明显改善患者认知功能。OBJECTIVE：To probe into the clinical efficacy of modified electroconvulsive therapy combined with risperidone in treatment of schizophrenia and effects on serum prolactin and cognitive function. METHODS ： 82 patients with schizophrenia admitted into the Affiliated Brain Hospital of Guangzhou Medical University/Guangzhou Huiai Hospital from Jan. 2015 to Jun. 2016 were selected to be divided into observation group and control group via the random number table, with 41 cases in each. The control group were treated with risperidone, while the observation group were additionally given modified electroconvulsive therapy based on the control group. Two groups were treated for a course of 8 weeks. RESULTS ： The total effective rate of observation group was significantly higher than that of control group, with statistically significant difference （ P 〈 0. 05 ）. After treatment of 8 weeks, the positive and negative symptoms points of observation group were significantly lower than those of control group. The serum prolactin levels of observation group was higher than that of control group. The graphics free recall, portrait features recall, lenovo learning, meaningless figure recognition and directed memory of observation group were significantly higher than those of control group, with statistically significant difference （ P 〈 0.05 ）. There was no statistically significant difference between two groups in the incidence of adverse drug reactions（P 〉 0.05）. CONCLUSIONS： The efficacy of modified electroconvulsive therapy combined with risperidone in treatment of schizophrenia is significant, and has few effects on serum prolactin, and can significantly improve the cognitive function of patients.

关 键 词：无抽搐电休克 利培酮 精神分裂症 疗效 泌乳素 认知功能 

分 类 号：R971.41[医药卫生—药品]