注射用双黄连(冻干粉末)联合乙酰半胱氨酸泡腾片预防非小细胞肺癌患者放射性肺炎的疗效观察  

Observation on Efficacy of Shuanghuanglian Injections Combined with Acetylcysteine Effervescent Tablets in Prevention of Radiation Pneumonitis in Non-small Cell Lung Cancer

作　　者：于卫江[1] 赵秀莉[1] 胡彦辉[2] 马东阳[2] YU Weijiang ZHAO Xiuli HU Yanhui MA Dongyang(Dept. of Pharmacy, the Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Henan Zhengzhou 450003, China Dept. of Traditional Chinese and Western Medicine, the Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, Henan Zhengzhou 450003, China)

机构地区：[1]郑州大学附属肿瘤医院/河南省肿瘤医院药学部,河南郑州450003 [2]郑州大学附属肿瘤医院/河南省肿瘤医院中西医结合科,河南郑州450003

出　　处：《中国医院用药评价与分析》2017年第4期454-456,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河南省医学科技攻关项目(No.201304056)

摘　　要：目的:探讨注射用双黄连(冻干粉末)联合乙酰半胱氨酸泡腾片预防非小细胞肺癌患者放射性肺炎的临床疗效。方法:选取2014年6月—2016年6月郑州大学附属肿瘤医院/河南省肿瘤医院收治的行放射治疗的非小细胞肺癌患者92例作为研究对象,以随机数字表法分为观察组和对照组,每组46例。对照组患者单纯行放射治疗,观察组患者在放射治疗开始前2 d给予注射用双黄连(冻干粉末)联合乙酰半胱氨酸泡腾片治疗,于放射治疗结束后停药。观察放射治疗结束后3个月,两组患者放射性肺炎的发生情况;采用美国肿瘤放射治疗协作组急性放射性损伤分级标准、Watters评分、卡氏评分评估患者肺损害程度、呼吸困难及身体机能情况。结果:治疗结束后3个月,观察组患者放射性肺炎发生率为13.33%(6/45),明显低于对照组的31.82%(14/44);观察组患者放射性肺炎损伤程度明显低于对照组;观察组患者Watters评分明显低于对照组,卡氏评分明显高于对照组,差异均有统计学意义(P<0.05)。结论:注射用双黄连(冻干粉末)联合乙酰半胱氨酸泡腾片用于非小细胞肺癌患者,可降低患者放射性肺炎的发生率,减轻急性放射性肺损害程度,对患者症状有积极作用。OBJECTIVE： To probe into the clinical efficacy of shuanghuanglian injections combined with Acetylcysteine effervescent tablets in prevention of radiation pneumonitis in non-small cell lung cancer. METHODS： 92 cases with non-small cell lung cancer accepting radiotherapy in the Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital from Jun. 2014 to jun. 2016 were selected to be divided into observation group and control group via the random number table, with 46 cases in each. The control group was given radiotherapy alone, while the observation group received shuanghuanglian injections and Acetylcysteine effervescent tablets at the beginning two days before radiotherapy, drugs were withdrawal after radio therapy. Three months after the end of radiotherapy, the incidence of radiation pneumonia of two groups were observed. Acute radiation injury scoring criteria by Radiation Therapy Oncology Group （RTOG）, Watters score and Karnofsky performance scale were used to evaluate the lung damage, dyspnea and somatic function of patients. RESULTS：Three months after the treatment, The incidence of radiation pneumonia of observation group was 13.33 % （6/45）, significantly lower than that of control group [ 31.82% （14/44） ] ; the degree of damage radioactive pneumonia of observation group was significantly lower than that of control group; the Watters score of observation group was significantly lower than that of control group, yet Karnofsky performance scale was significantly higher than that of control group; with statistically significant difference （P 〈 0.05 ）. CONCLUSIONS ： Shuanghuanglian injections combined with Acetylcysteine effervescent tablets in prevention of radiation pneumonitis in non-small cell lung cancer can decrease the incidence of radiation pneumonia in non-small cell lung cancer, and reduce the lung damage and play active role in relieve patients＇ symptoms.

关 键 词：注射用双黄连(冻干粉末) 乙酰半胱氨酸泡腾片 非小细胞肺癌 放射性肺炎 预防 

分 类 号：R974[医药卫生—药品]