小剂量阿司匹林对老年高血压前期人群临床干预的研究  

Clinical study of low-dose aspirin intervention elderly patient for prehypertension

作　　者：黄先勇[1] 王家宏[2] 陈永增[2] 尹良 彭志睛 常青[1] 王红霞[1] 孙婷婷[1] 朱连荣[3] Huang Xianyong Wang Jiahong Chen Yongzeng et al(Health Care Department of PLA General Hospital Hainan Branch, Sanyan 572013, China)

机构地区：[1]解放军总医院海南分院保健科,三亚572013 [2]解放军总医院国际一科 [3]解放军总医院海南分院保健办公室,三亚572013

出　　处：《中华保健医学杂志》2017年第2期115-117,共3页Chinese Journal of Health Care and Medicine

基　　金：海南省自然科学基金面上项目(20168363);国家科技支撑计划课题(2012BA137B04)

摘　　要：目的探讨小剂量阿司匹林对延缓老年高血压前期患者病情进展及靶器官保护作用的效果。方法选取2013年10月~2014年5月解放军总医院就诊的800例年龄、性别相匹配的老年高血压前期患者,随机分成常规干预组和药物干预组2组,每组400例。常规干预组接受生活方式调整,药物干预组在调整生活方式的基础上每晚服用阿司匹林100 mg。对比分析干预前后2组血压、血浆肾素活性、血管紧张素、醛固酮水平、踝肱指数、血管内皮功能、高敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)及单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)浓度的变化。结果药物干预组高血压前期患者2年内进展为临床高血压明显低于常规干预组[43.5%vs 26.5%,P<0.05],且药物干预组高血压前期患者各项指标明显好于常规干预组。结论小剂量阿司匹林能明显延缓老年高血压前期患者病情进展及靶器官保护作用的效果。Objective To study the effect of low-dose aspirin on prehypertension patients in delaying disease progression and target organ protection. Methods In total, 800 prehypertension patients were selected in PLA general hospital during October 2013 to May 2014; the patients were divided randomly into two groups：one group （the control group） underwent lifestyle adjustment,and the other group （the experimental group） additionally took 100 mg of aspirin. Differences in the following parameters were analyzed between the two groups before and after the intervention： blood pressure,plasma renin activity,angiotensin levels,aldosterone levels, ankle brachial index,endothelial function,high-sensitivity c-reactive protein （hs-CRP）levels and monocyte chemotactic protein 1 （MCP-1） levels. The effect of low-dose aspirin on the early stage of high blood pressure was analyzed. Results Fewer patients progressed into clinical hypertension in the experimental group than in the control group after 2 years （106 patients （26.5%） vs 174 patients （43.5%）,P 〈 0.05）,and the clinical indicators were clearly better in the experimental group than in the control group. Conclusion Low-dose aspirin can significantly slow the progression of prehypertension and protect target organs.

关 键 词：阿司匹林 高血压前期 预防 老年人 

分 类 号：R544.1[医药卫生—心血管疾病]