肾衰宁胶囊对慢性肾功能衰竭患者营养状况及血液流变学的影响  

Effect of Shenshuaining capsule on nutritional status and blood rheology in patients with chronic renal failure

作　　者：杨勇[1] 王霄一[1] 丁敏[1] 冯跃华[1] 

机构地区：[1]湖州师范学院附属第一医院肾内科,浙江省湖州313000

出　　处：《中国基层医药》2017年第10期1450-1454,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省卫生厅课题（2009B154）

摘　　要：目的 探讨肾衰宁胶囊对慢性肾功能衰竭患者营养状况及血液流变学的影响.方法 采用抽签法随机抽取慢性肾功能衰竭患者150例为研究对象,采用随机数字表法分为观察组和对照组,各75例.对照组用血液透析机分别进行血液透析.观察组在对照组治疗基础上,每周透析结束后,辅以肾衰宁胶囊口服治疗.观察两组临床疗效、营养状况及生化指标.结果 观察组总有效率86.67%,高于对照组的72.00%,差异有统计学意义（χ^2=4.920,P〈0.05）.治疗后,观察组相关营养指标[HBG（135.7±16.4）g/L、ALB（34.5±2.9）g/L、IgG（10.8±0.7）g/L、IgA（2.1±0.4）g/L及IgM（1.7±0.3）g/L]等高于对照组[HBG（113.8±16.9）g/L、ALB（28.4±2.5）g/L、IgG（7.6±0.8）g/L、IgA（1.3±0.3）g/L及IgM（1.2±0.2）g/L],差异均有统计学意义（t=8.054、13.797、26.070、13.856、12.010,均P〈0.01）.观察组营养低下率为25.33%,低于对照组的46.67%,差异有统计学意义（χ^2=45.905,P〈0.05）.观察组治疗后的血肌酐[（349±64）μmol/L]和尿素氮[（10.4±3.7）mmol/L]均低于对照组治疗后的血肌酐[（462±51）μmol/L]和尿素氮[（14.2±4.5）mmol/L],差异有统计学意义（t=11.958、5.649,均P〈0.05）.观察组治疗后的肌酐清除率[（25.1±6.1）mL/min]和血红蛋白浓度[（92.1±21.1）g/L]均高于对照组治疗后的肌酐清除率[（21.7±5.4）mL/min]和血红蛋白浓度[（84.7±15.3）g/L],差异有统计学意义（t=3.614、2.459,均P〈0.01）.观察组治疗后的全血高切黏度[（3.59±0.94）mPa/s]、全血低切黏度[（7.84±0.97）mPa/s]、血浆黏度[（1.31±0.15）mPa/s]、红细胞比容[（0.33±0.07）]均低于对照组治疗后的全血高切黏度[（4.41±1.13）mPa/s]、全血低切黏度[（8.72±1.05）mPa/s]、血浆黏度[（1.43±0.24）mPa/s]、红细胞比容[（0.42±0.05）],差异均有统计学意义（t=11.958、5.649、3.614、2.459,均P〈0.01）.结论 肾衰宁胶囊联合血液透析可Objective To explore the effect of Shenshuaining capsule on nutritional status and blood rheology in patients with chronic renal failure.Methods 150 cases of chronic renal failure were randomly selected and were randomly divided into observation group and control group, 75 cases in each group.The control group were given hemodialysis for treatment,and the observation group was treated with Shenshuaining capsule one week after dialysis.The clinical effect,nutritional status and biochemical indicators in the two groups were observed.Results The total effective rate in the observation group was 86.67%, which was higher than 72.00% in the control group,the difference was statistically significant（χ^2=4.920,P〈0.05）.After treatment,the nutrition indicators of HBG,ALB,IgG,IgA and IgM in the observation group were （135.7±16.4）g/L,（34.5±2.9）g/L,（10.8±0.7）g/L,（2.1±0.4）g/L and （1.7±0.3）g/L respectively, which were higher than those in the control group[（113.8±16.9）g/L,（28.4±2.5）g/L,（7.6±0.8）g/L,（1.3±0.3）g/L and （1.2±0.2）g/L], the differences were statistically significant（t=8.054,13.797,26.070,13.856,12.010,all P〈0.01）.In the observation group,the incidence rate of undernutrition was 25.33%, which was lower than 46.67% in the control group, the difference was statistically significant（χ^2=45.905,P〈0.05）.After treatment,the blood urea nitrogen and blood urea in the observation group were （349±64）μmol/L and （10.4±3.7）mmol/L respectively,which were lower than those in the control group[（462±51）mol/L and （14.2±4.5）mmol/L], the differences were statistically significant（t=11.958,5.649,all P〈0.05）.After treatment,the creatinine clearance rate and concentration of hemoglobin in the observation group were （25.1±6.1）mL/min and （92.1±21.1）g/L respectively, which were higher than those in the control group[（21.7±5.4）mL/min and （84.7±15.3）g/L], the differences were statistically significant（t=3.614,2.459,all P〈0.01�

关 键 词：肾衰宁胶囊 血液透析 慢性肾功能衰竭 营养状况 血液流变学 

分 类 号：R692.5[医药卫生—泌尿科学]