降钙素原检测对细菌与病毒感染的鉴别诊断价值  

Differential diagnostic value of the detection of calcitonin for bacterial and viral infections

作　　者：陆英[1] 胡昌弟[1] 杨春英[1] 

机构地区：[1]浙江省常山县人民医院检验科,324200

出　　处：《中国基层医药》2017年第10期1482-1486,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 观察降钙素原（PCT）检测在细菌性感染和病毒性感染鉴别中的临床作用.方法 选择感染患者150例,其中病毒感染患者50例作为病毒感染组,细菌感染患者100例作为细菌感染组.选择同期在该院进行健康体检、外周血培养为阴性健康者50例作为对照组.观察细菌性感染和病毒性感染患者血液中PCT浓度,并与对照组相比较.观察各种细菌感染的PCT浓度,以及各种病毒感染PCT浓度.结果 细菌感染组PCT（8.023±3.542）ng/mL,明显高于对照组的（0.031±0.011）ng/mL,差异有统计学意义（t=15.960,P=0.000）,病毒感染组PCT水平（0.032±0.008）ng/mL,与对照组的（0.031±0.011）ng/mL差异无统计学意义（t=1.903,P=0.059）.在不同的细菌感染性疾病中,脓毒血症的PCT水平最高,为（27.544±4.511）ng/mL,其次为细菌性腹膜炎和感染性胰腺炎,分别为（5.131±1.231）ng/mL、（4.941±1.665）ng/mL,蜂窝组织炎的PCT水平最低,为（1.129±0.415）ng/mL.各种病毒感染患者EB病毒感染略高（0.027±0.002）ng/mL,麻疹病毒感染略低（0.021±0.002）ng/mL,整体PCT水平差异无统计学意义.结论 降钙素原对于细菌性感染和病毒性感染的鉴别具有重要意义,能够为临床治疗方案的制定提供可靠依据.Objective To observe the clinical effect of calcitonin（PCT） in the identification of bacterial infection and viral infection.Methods 150 cases were randomly selected,including 50 cases of viral infection,100 cases of bacterial infection.The people with physical examination at the same period in the hospital whose peripheral blood culture were negative were selected as control group.PCT concentrations of various bacterial infections were observed,as well as the concentrations of PCT in various viral infections,and compared with the control group.Results The PCT level in the bacterial infection group was （8.023±3.542）ng/mL, which was significantly higher than （0.031±0.011）ng/mL in the control group（t=15.960,P=0.000）.There was no significant difference in the level of PCT between the viral infection group [（0.032±0.008）ng/mL] and the control group [（0.031±0.011） ng/mL] （t=1.903,P=0.059）.In different bacterial infections,the PCT level in sepsis was the highest [（17.544±4.511）ng/mL],followed by bacterial peritonitis and infectious pancreatitis[（5.131±1.231）ng/mL,（4.941±1.665）ng/mL].The PCT level of cellulitis was the lowest [（27.544±4.511）ng/mL].Of a variety of viral infections,the patients with EB virus infection had slightly higher PCT level[（0.027±0.002）ng/mL],which of measles virus infection was slightly lower[（0.021±0.002）ng/mL],the overall PCT level had no significant difference.Conclusion It is important to identify the bacterial infection and viral infection, which can provide a reliable basis for clinical treatment.

关 键 词：降钙素 细菌 病毒 感染 

分 类 号：R446.6[医药卫生—诊断学] R51[医药卫生—临床医学]