戊乙奎醚与阿托品治疗急性有机磷农药中毒的临床疗效比较  

Comparison of clinical efficacy of penehyclidine hydrochloride and atropine in the treatment of acute organophosphorus pesticide poisoning

作　　者：李皖生[1] 徐道剑 刘霖敏[1] 卢翔[1] 陈金良[1] 

机构地区：[1]台州市立医院急诊科,浙江省台州318000

出　　处：《中国基层医药》2017年第10期1520-1523,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 比较戊乙奎醚与阿托品治疗急性有机磷农药中毒的临床疗效.方法 选取86例有机磷农药中毒的患者,按照随机数字表法将其分为对照组和观察组,每组43例,两组均给予常规的抢救治疗,在此基础上,对照组加用阿托品,观察组加用戊乙奎醚,观察两组主要症状消失时间、抢救成功率及不良反应.结果 经抢救治疗后,观察组抢救成功率（97.8%）与对照组（88.4%）比较差异有统计学意义（χ^2=1.433,P〈0.05）;观察组M样症状、N样症状及中枢神经系统症状消失时间较对照组显著缩短（P〈0.05）;观察组用药次数、用药剂量、胆碱酯酶复原时间及住院时间与对照组比较差异均有统计学意义（均P〈0.05）;对照组出现视力模糊、躁动、心动过速及尿潴留的发生率明显高于观察组,两组差异均有统计学意义（均P〈0.05）.结论 戊乙奎醚用于急性有机磷农药中毒抢救,可显著降低各种症状发生率,缩短症状消失时间,减少住院时间,提高抢救效率,降低不良反应发生率,具有安全、有效、快速等特点,有临床借鉴意义.Objective To compare the clinical effect of penehyclidine hydrochloride and atropine in the treatment of acute organophosphorus pesticide poisoning.Methods 86 patients with organophosphorus pesticide poisoning were selected and randomly assigned to the observation group and the control group according to the digital table,43 cases in each group.The two groups were given conventional treatment,while the control group was treated with atropine,the observation group was given penehyclidine hydrochloride.The disappearance time of main symptoms, rescue success rate and adverse reactions of the two groups were observed.Results After salvage treatment, the rescue success rate of the observation group was 97.8%,which of the control group was 88.4%,the difference was statistically significant （χ^2=1.433,P〈0.05）.The disappear time of M like symptoms,N like symptoms and central nervous system symptoms in the observation group was significantly shorter compared with the control group （all P〈0.05）.The number of drugs,dosage,cholinesterase recovery time and hospitalization time between the two groups had statistically significant differences （P〈0.05）.The incidence rates of blurred vision,restlessness,heart rate and urinary retention in the control group were significantly higher than those in the observation group （all P〈0.05）.Conclusion Penehyclidine hydrochloride for acute organophosphorus pesticide poisoning can significantly reduce the incidence of symptoms,shorten the disappearance time of symptoms,reduce hospitalization time,improve the efficacy of rescue,reduce the incidence of adverse reactions, it is safe,effective and has great clinical significance.

关 键 词：有机磷农药中毒 戊乙奎醚 阿托品 

分 类 号：R595.4[医药卫生—内科学]