白癜风进展期患者甲状腺功能状况与CD_4^+CD_(25)^+T细胞水平关系的研究  

Study on the relationship between thyroid function and CD_4^+CD_(25)^+ T cell level in patients with vitiligo in progression period

作　　者：李晓晴[1] 惠海英[1] 苏亚妮[2] Li Xiaoqing Hui Haiying Su Yani(Department of Dermatology, Shaanxi Provincial People＇s HospitaK Xi＇an 710068)

机构地区：[1]陕西省人民医院皮肤科,西安710068 [2]陕西省人民医院统计室,西安710068

出　　处：《陕西医学杂志》2017年第5期667-668,共2页Shaanxi Medical Journal

基　　金：陕西省社会发展科技攻关项目(2015SF162)

摘　　要：目的:探讨白癜风发病与甲状腺功能及CD_4^+CD_25^+调节性T细胞水平之间的相关性。方法:病例组为白癜风进展期患者80例,对照组为健康查体者50例。分别采用化学发光法检测两组受试者血清中抗甲状腺过氧化物酶抗体(TPOAb)和抗甲状腺球蛋白抗体(TGAb)水平,通过流式细胞仪测定受试者外周血中CD_4^+CD_25^+调节性T细胞水平,并对两组结果分别进行比较。结果:病例组患者血清中TPOAb和TGAb阳性率均高于健康对照组(P<0.05),而病例组患者外周血CD_4^+CD_25^+调节性T细胞百分率低于健康对照组(P<0.05)。结论:白癜风进展期患者存在甲状腺功能异常与细胞免疫功能异常,三者之间存在一定的相关性。Objective： To investigate the correlation between the incidence of vitiligo with in progression peri-od and thyroid function and the level of CD4 ＋ CD25 ＋ T cells. M e th o d s： Chemiluminescence was applied to test the serum levels of TPOAb, TGAb and in 80 patients with vitiligo in progression period and 50 controls. At the same time, the peripheral blood of CD4 ＋ CD25 ＋ T lymphocytes were examined and compared. R e su l t s： The positive rate of TPOAb and TGAb in the serum of patients with vitiligo significantly higher than healthy controls （P〈0. 05 ）; The level of CD4 ＋ CD25＋ T cells in peripheral blood of patients in case group was lower than that in healthy control group （P〈0. 05）. Conclusion： Patients with vitiligo in progression period with abnormal thyroid function and cellu-lar immune function abnormalities. It is worthy of attention in clinical diagnosis and treatment.

关 键 词：白癜风/血液 甲状腺功能试验 @CD4+CD25+ @调节性T细胞 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]