地特胰岛素联合复方丹参滴丸对2型糖尿病合并冠心病病人炎性因子水平、调控因子活性和胰岛素抵抗的影响  

Influence of Detemir Insulin and Compound Danshen Dripping Pill on the Inflammatory Cytokines,Regulatory Factor Activity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus and Coronary Heart Disease

作　　者：孟宪杰[1] 李莉[1] 常绍菊[1] 李会[1] 曹丽慧[1] 杨柳[1] 张丽华[1] Meng Xianjie Li Li Chang Shaoju Li Hui Cao Lihui Yang Liu Zhang Lihua(Tangshan People＇s Hospital, Tangshan 063000, Hebei,Chin)

机构地区：[1]河北省唐山市人民医院,河北唐山063000

出　　处：《中西医结合心脑血管病杂志》2017年第9期1093-1096,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的研究地特胰岛素联合复方丹参滴丸对2型糖尿病合并冠心病病人炎性因子水平、调控因子活性和胰岛素抵抗的影响。方法选择于2014年2月1日—2015年2月1日在我院接受治疗的2型糖尿病合并冠心病病人109例。依据随机分组原则将病人分为治疗组(55例)及对照组(54例)。所有病人均给予冠心病二级预防治疗及糖尿病相关知识教育。对照组每日一次给予注射地特胰岛素注射液,治疗组给予地特胰岛素联合复方丹参滴丸,一次口服10丸,每日3次。治疗时间为两个疗程,1个疗程为4周。观察并分析治疗前后炎症因子水平、调节因子活性及胰岛素抵抗改善情况。结果在两个疗程治疗后,两组治疗效果均较治疗前明显改善,差异具有统计学意义(P<0.05)。而对比两组间,治疗组的改善效果好于对照组,且差异具有统计学意义(P<0.05)。结论对于2型糖尿病合并冠心病病人,治疗方案选用地特胰岛素联合复方丹参滴丸,可明显降低炎症因子水平、降低调节因子活性,改善胰岛素抵抗,使血糖控制良好、症状明显改善,减少冠心病急性发病危险。Objective To study the influence of detemir insulin and compound Danshen dripping pill （CDDP） on the inflammatory cytokines, regulatory factor activity and insulin resistance in patients with type 2 diabetes mellitus （T2DM） and coronary heart disease （CHD）. Methods One hundred and nine patients with T2DM and CHD were randomly divided into two groups：control group（n = 54） treated with detemir insulin.and treatment group （n = 55） treated with detemir insulin and CDDP for 8 weeks.The levels of inflammatory cytokines. regulatory factor activity and insulin resistance were observed before and after treatment. Results After treat-ment, the effects were improved in two groups.which was better in treatment group than that in control group （ P 〈0.05） .Conclusion Detemir insulin and CDDP can significantly reduce the levels of inflammatory factors and the activity of regulatory factors. improve insulin resistance.

关 键 词：2型糖尿病 冠心病 地特胰岛素 复方丹参滴丸 炎性因子 调控因子 胰岛素抵抗 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]