146例卡马西平药品不良反应文献分析  

Literature Analysis of 146 Cases of Adverse Drug Reactions Induced by Carbamazepine

作　　者：潘骊[1] 李素华[1] 张晓乐[1] 

机构地区：[1]大连大学附属中山医院,辽宁大连116001

出　　处：《中国药物警戒》2017年第4期230-234,共5页Chinese Journal of Pharmacovigilance

摘　　要：目的研究卡马西平致药品不良反应(ADR)的规律和特点,为临床合理用药提供参照。方法以"卡马西平"、"不良反应"、"致"、"carbamazepine"、"CMP"为检索词,检索中国期刊网全文数据库,依纳入与排除标准对文献资料进行提取与统计分析。结果共纳入52篇文献,146例病例,194例次ADR。累及系统-器官主要为皮肤及其附件损害、神经和精神系统损害、心血管系统损害和血液系统损害等,其中以皮肤及附件损害最为常见,包括大疱表皮坏死松解型药疹、剥脱性皮炎等,严重者致器官衰竭,甚至致死。结论临床合理使用卡马西平时,应重视其ADR监测,尤其应警惕该药导致的重型药疹,确保用药安全。Objective Through investigating the characteristics and mechanism of adverse drug reactions （ ADRs） induced by carbamazepine, to find its risk factors and provide technical support for safe and rational use of drugs in clinic. Methods Using “ carbamazepine”,“adverse reaction” and “ to” as key words to search and retrieve articles in the CNKI database. According to inclusion and exclusion criteria to analyze the literature. Results A total of 52 papers, 146 cases, 194 series of ADR were included. Systems and organs mainly involved in ADRs were skin and its appendages, neurological and psychiatric system damage, cardiovascular system damage, blood system damage, etc. The skin and appendages damage was the most common reported ADRs, including bullous epidermal necrolysis, exfoliative dermatitis, etc. It causes severe organ failure and even death. Conclusion It is important to pay attention to the ADR caused by carbamazepine, strengthen clinical rational use of drugs, in order to prevent ADR and ensure the safe drug use in clinic.

关 键 词：卡马西平 药品不良反应 文献分析 

分 类 号：R994.11[医药卫生—毒理学]