蛇毒抗肿瘤成分的研究进展  

The progress of the anti-tumor components of snake venom

作　　者：赵健楠[1] 孙晋民[2] 

机构地区：[1]中国医科大学,沈阳110013 [2]中国医科大学科学实验中心,沈阳110013

出　　处：《西北药学杂志》2017年第3期391-393,共3页Northwest Pharmaceutical Journal

基　　金：辽宁省科技基金项目(编号:2008225021-1);辽宁省科技基金项目(编号:2013225021);专利:国家知识产权局发明专利第476108号

摘　　要：目的探讨蛇毒抗肿瘤成分的作用及其在医药领域的应用,为蛇毒成分在抗肿瘤领域的研发提供参考。方法查阅并总结资料文献,对国内外蛇毒抗肿瘤成分的研究进行综述。结果蛇毒具有多种抗肿瘤成分,对多种肿瘤均有抑制作用,可抑制肿瘤相关的基因表达、抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡和抑制肿瘤血管再生与转移等。结论对蛇毒抗肿瘤成分进行深入研究,开发其在抗肿瘤药物研究领域的价值。Objective To explore the application of the anti-tumor components of snake venom in the field of medicine and to provide a reference for research of the components of snake venom in the field of anti-tumor.Methods The literature of research and review of the anti-tumor components of snake venom both at domestic and abroad were summarized.Results Snake venom contained a variety of anti-tumor components by inhibiting the expression of tumor-related gene,the proliferation of tumor cell,tumor angiogenesis and inducing the apoptosis of tumor cell.Conclusion Study of the anti-tumor components of snake venom in depth has great value in the field of anti-tumor drugs research.

关 键 词：蛇毒 抗肿瘤 抗肿瘤成分 

分 类 号：R979.1[医药卫生—药品]