2011—2015年上海市黄浦区疑似预防接种异常反应监测结果  

Results of surveillance of adverse events following immunization in Huangpu District of Shanghai City from 2011-2015

作　　者：王婧[1] 姜铭波[1] 陆瑾[1] 何景雄[1] 

机构地区：[1]上海市黄浦区疾病预防控制中心免疫规划科,上海200023

出　　处：《职业与健康》2017年第5期669-672,共4页Occupation and Health

摘　　要：目的分析上海市黄浦区2011—2015年疑似预防接种异常反应(Adverse Event Following Immunization,AEFI)的报告情况和发生特征。方法通过全国AEFI信息管理系统(AEFI Information Management System,AEFIIMS),收集2011年1月1日—2015年12月31日黄浦区报告的个案数据,采用描述方法对相关指标进行分析。结果 2011年—2015年,黄浦区共报告AEFI个案1 542例,男女比例为1.23∶1,<1岁的占39.3%,1~2岁占36.38%。报告发生AEFI前3位的疫苗为:百日咳-白喉-破伤风联合疫苗、百白破-灭活脊灰-b型流感嗜血杆菌疫苗、白喉-破伤风联合疫苗。接种第1剂次后发生的占49.9%,接种后≤1 d发生的占90.20%。报告发病率2011年174.65/10万,2012年162.01/10万,2013年151.60/10万,2014年145.58/10万,2015年164.07/10万。AEFI分类诊断中,一般反应1 348例(占87.42%),异常反应184例(占11.93%),92.74%的个案痊愈。讨论黄浦区AEFI监测系统的敏感性有待提高,另外还要加强对预防接种风险知识的宣传,防止媒体过度夸大预防接种不良反应的影响,提高公众对预防接种的信心。[ Objective ] To analyze the reporting status and occurrence features of Adverse Event Following Immunization （AEFI） in Huangpu District of Shanghai from 2011-2015. [ Methods ] The data of AEFI cases from January 1,2011 to December 31,2015 in Huangpu District were collected through AEFI Information Management System （AEFIIMS）, and were analyzed by descriptive methodology. [Results] Totally 1 542 AEFI cases were reported in Huangpu District from 2011-2015, with the male-to-female ratio of 1.23：1. The patients below 1 year old and patients aged 1-2 years old accounted for 39.3% and 36.38% respectively. The top three vaccines with most cases were pertussis-diphtheria-tetanus combined vaccine（DTP）, DTP-inactivated polio-aemophilus influenza type B vaccine, and diphtheria-tetanus combined vaccine. 49.9% cases reported after the first dose and 90.20% occurred within the first day after vaccination. The reported incidence rate was 174.65/lakh in 2011,162.01/lakh in 2012,151.60/lakh in 2013,145.58/lakh in 2014, and 164.07/lakh in 2015. 1 348 （87.42%） cases were classified as common reaction, and 184（11.93%） cases were paradoxical reaction. 92.74% cases were cured. [Conclusion~ The susceptibility of AEFI surveillance system needs to be improved in Huangpu District. Moreover, it is necessary to strengthen the publicity of knowledge about vaccination risk to prevent the impact of adverse vaccination effects which would be easily exaggerated by media, and enhance people＇s confidence of immunization.

关 键 词：疑似预防接种异常反应 监测 

分 类 号：R186[医药卫生—流行病学]