葡萄糖代谢调控T细胞功能的研究进展  

New perspectives of glucose metabolism in T-Cell function

作　　者：王昌理[1] 薄禄龙[1] 邓小明[1] 

机构地区：[1]第二军医大学长海医院麻醉科,上海200433

出　　处：《国际免疫学杂志》2017年第2期173-177,共5页International Journal of Immunology

基　　金：国家自然科学基金面上项目（81671887,81471845,81272065）;上海青年医师资助计划（20141093）

摘　　要：T细胞接受复杂的信号后激活、增殖和分化成不同的细胞亚型。研究表明，葡萄糖代谢可影响T细胞的激活、分化和免疫功能。因此，了解T细胞葡萄糖代谢特点和部分调控葡萄糖代谢的信号分子，探讨葡萄糖代谢的改变如何影响T细胞功能很有必要，深入探索T细胞的葡萄糖代谢特点和调控机制，有助于研究炎症条件下T细胞的功能，从而为炎症的治疗提供新的方法和思路。After receiving a series of complex and coordinated signals, T cells are activated, proliferate, and differentiate into diverse T cell subsets. Previous evidences suggest that glucose metabolism plays a vital role in the activation, differentiation and immune function of T cells. Therefore, we review the characteristics of glu- cose metabolism in T cells and several important signaling molecules which regulate glucose metabolism. Fur- thermore, the mechanisms by which glucose metabolism regulates the function of T cells are discussed. A thor- ough exploration of the above topics could facilitate our understanding on the function of T cells in inflammatory conditions, which can provide new therapeutic approaches in the future.

关 键 词：代谢 氧化磷酸化 糖酵解 T淋巴细胞 

分 类 号：R392[医药卫生—免疫学]