肾康注射液联合贝那普利对慢性肾小球肾炎患者外周血IFN-γ,IL-4及IL-17水平的影响  

Effects of Shenkang Injection and Benazepril on Peripheral Blood Levels of IFN-γ, IL-4 and IL-17 in Patients with Chronic Glomerulonephritis

作　　者：杨涛[1] 张韬[2] 陈华茜[1] 张任[1] 赵黎[1] 李正东[1] 

机构地区：[1]湖北医药学院附属东风医院肾内科,湖北十堰442000 [2]湖北医药学院附属东风医院中医内科,湖北十堰442000

出　　处：《现代生物医学进展》2017年第13期2542-2545,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(99142)

摘　　要：目的:探讨肾康注射液联合贝那普利治疗慢性肾小球肾炎的临床效果及对患者外周血干扰素-γ(INF-γ)、白介素-4(IL-4)、白介素-17(IL-17)水平的影响。方法:选择2013年5月至2016年5月我院接诊的96例慢性肾小球肾炎患者,随机法分为观察组(n=48)和对照组(n=48)。对照组患者采用贝那普利治疗,观察组患者在对照组基础上采用肾康注射液治疗。观察并比较两组患者治疗前后收缩压(SBP)、舒张压(DBP)、尿素氮(BUN)、尿肌酐(UCr)、血肌酐(SCr)、24 h尿蛋白定量及血清INF-γ,IL-17和IL-4水平,以及临床疗效。结果:治疗后,观察组患者收缩压(SBP)、舒张压(DBP)低于对照组(P<0.05);观察组患者尿素氮(BUN)、尿肌酐(UCr)、血肌酐(SCr)、24 h尿蛋白定量低于对照组(P<0.05);观察组患者血清INF-γ及IL-17水平低于对照组,而IL-4水平高于对照组(P<0.05);观察组临床总有效率高于对照组(P<0.05);两组患者不良反应总发生率无显著差异(P>0.05)。结论:在慢性肾小球肾炎使用肾康注射液联合贝那普利效果显著,值得应用推广。Objective：To study the effects of Shenkang injection and benazepril on the serum levels of IFN-γ,IL-4 and IL-17 in patients with chronic glomemlonephritis and its clinical efficacy.Methods：96 patients with chronic glomerulonephriti who were treated in our hospital from May 2013 to May 2016 were selected and randomly divided into the observation group （n=48） and the control group （n=48）.The patients in the control group were treated with benazepril,while the patients in the observation group were treated with Shenkang injection on the basis of the control group.Then the changes of systolic blood pressure （SBP）,diastolic blood pressure （DBP）,serum levels of urea nitrogen （BUN）,urinary creatinine （UCr）,serum creatinine （SCr）,24 h urinary protein,IFN-γ,IL-4 and 1L-17,and the clinical efficacy between the two groups were observed and compared before and after the treatment.Results：After treatment,the systolic blood pressure （SBP） and diastolic blood pressure （DBP） in the observation group were lower than those of the control group （P〈0.05）;After treatment,the levels of urea nitrogen （BUN）,urinary creatinine （UCr）,serum creatinine （SCr） and 24 h urinary protein in the observation group were lower than those of the control group （P〈0.05）;After treatment,the levels of IFN-γand IL-17 in the observation group were lower than those of the control group,while the IL-4 was higher （P〈0.05）;The total effective rate in the observation group was higher than that of the control group （P〈0.05）;There was no statistically significant difference in the incidence of adverse reactions between the two groups （P〉0.05）.Conclusions：Shenkang injection combined with benazepril has obvious curative effects on the treatment of chronic glomerulonephritis,which is worthy of clinical application.

关 键 词：慢性肾小球肾炎 肾康注射液 贝那普利 肾功能 

分 类 号：R692.3[医药卫生—泌尿科学]