2型糖尿病患者血清LDL,CysC与动脉粥样硬化的相关性研究  

The Relationship between Levels of LDL, Cys C and Atherosclerosis in Patients with Type 2 Diabetes Mellitus

作　　者：张鹏[1] 蒋兰兰[1] 罗勇[1] 许向红[1] 袁璐[1] 马建华[1] 

机构地区：[1]南京市第一医院内分泌科,江苏南京210000

出　　处：《现代生物医学进展》2017年第15期2862-2864,2883,共4页Progress in Modern Biomedicine

基　　金：江苏省自然科学计划项目(20140152)

摘　　要：目的:分析2型糖尿病(T2DM)患者血清低密度脂蛋白(LDL)、胱抑素C(CysC)与动脉粥样硬化(AS)的相关性。方法:选取2型糖尿病患者300名,根据颈动脉内膜中膜厚度分为非动脉粥样硬化斑块组(n=109)和动脉粥样硬化斑块组(n=191),并对动脉粥样硬化斑块的相关危险因素进行多因素Logistic回归分析。结果:(1)Pearson相关分析显示,LDL、CysC水平与IMT值呈正相关(P<0.05)。(2)单因素分析示,非AS组和AS组两组间LDL(t=8.876,P<0.05)、CysC(t=7.985,P<0.05)、HbA1c(t=9.912,P<0.05)、Hs-CRP(t=12.461,P<0.05)、年龄(t=7.114,P<0.05)、UA((t=8.618,P<0.05)间差异有统计学意义;(3)多因素Logistic回归分析示,LDL、CysC、HbA1c、年龄是T2DM并AS的独立危险因素(P<0.05);结论:LDL与CysC水平是T2DM并AS的独立危险因素。Objective：To observe the relationship between levels of low density lipoprotein （LDL）,Cystatin C （CysC） and Atherosclerosis （AS） in patients with Type 2 diabetes mellitus（T2DM）.Methods：300 cases with T2DM were selected.According to the carotid intima-media thickness （IMT）,patients were divided into two groups：AS group （n=191） and non-AS group （n=109）.A multi-factor Logistic regression was performed to analyze the risk factors associated with the incidence of T2DM complicated with AS.Results：（1） Pearson correlation analysis indicated that CysC and LDL levels were positively correlated with IMT （P〈0.05）;（2） Univariate analysis showed that the incidence of AS was associated with HbAlc （t=9.912,P〈0.05）,CysC （t=7.985,P〈0.05）,LDL （t=7.592,P〈0.05）,age （t=7.114,P〈0.05）,UA （t=8.618,P〈0.05）,Hs-CRP （t=12.461,P〈0.05）.（3） Multi-factor Logistic regression indicated that LDL,CysC,HbAlc and age were the independent risk factors for the onset of AS （P〈0.05）.Conelusions：It is proved that LDL and CysC were the independent risk factors for the onset of AS with T2DM.

关 键 词：2型糖尿病 动脉粥样硬化 低密度脂蛋白 胱抑素C 颈动脉内-中膜厚度 

分 类 号：R587.2[医药卫生—内分泌]