艾滋病患者CD4^+T细胞基线值与长期高效抗逆转录病毒治疗免疫重建效果的相关性研究  

Study on the Correlation of CD4^+T Cell Baseline Values in HIV/AIDS Patients and the Effect of Long-Term and Highly Active Antiretroviral Therapy

作　　者：朱勇[1] 李丽[1] 郭燕[2] 王卯[3] 陈海娟[4] 

机构地区：[1]新疆医科大学第一附属医院感染性疾病中心,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院预防保健科,新疆乌鲁木齐830054 [3]新疆昌吉州人民医院心血管内科,新疆昌吉831100 [4]新疆昌吉州人民医院干部综合内科,新疆昌吉831100

出　　处：《现代生物医学进展》2017年第15期2880-2883,共4页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区科技厅科技支疆项目(201491175)

摘　　要：目的:探讨艾滋病患者CD4^+T细胞基线值与长期高效抗逆转录病毒治疗免疫重建效果的相关性。方法:挑选进行长期高效抗逆转录病毒治疗的艾滋病患者120例,并按CD4^+T淋巴细胞计数基线值分为A组(≤100·μL^(-1))共66例和B组(>100·μL^(-1))共54例,对两组患者的CD4^+T以及CD8^+T淋巴细胞计数变化进行定期观察以及统计分析。结果:经抗病毒治疗后,B组患者各个阶段的CD4^+T淋巴细胞计数回升水平明显优于A组,差异具有统计学意义(均P<0.001);9个月内,B组CD4^+T淋巴细胞计数回升明显优于A组,差异具有统计学意义(P=0.003,P<0.001,P=0.002);12个月后,两组患者CD4^+T淋巴细胞计数增幅并无明显差异,无统计学意义(P=0.061,P=0.219,P=0.738);经抗病毒治疗后,两组组患者各个阶段的CD8^+T淋巴细胞计数回升水平均无明显差异,无统计学意义(P=0.447,P=0.681,P=0.639,P=0.464,P=0.886,P=0.712)。结论:艾滋病患者免疫重建受CD4^+T淋巴细胞基线高低的直接影响,而CD8^+T淋巴细胞计数的回升相对较为缓慢。Objective：To explore the correlation of CD4＋T cell baseline values in HIV / AIDS patients and the effects of long-term and highly effective anti retroviral therapy.Methods：Selected 120 case of patients with HIV / AIDS treated with long-term and highly active antiretroviral therapy.According to CD4＋T lymphocyte count baseline,they were divided into group A （≤ 100· μ L^-1,a total of 66 eases） and group B （〉 100·μL^-1,a total of 54 cases）.The changes of CD4^＋T and CD8^＋T lymphocyte count were observed and statistically analyzed in the two groups.Results：After the antiviral therapy,the CD4＋T lymphocyte count in each stage of the group B was significantly better than that in the group A,and the difference was statistically significant （all P〈0.001）.Within 9 months,the CD4＋T lymphocyte count in group B was significantly better than that in group A,with statistical difference （P=0.003,P〈0.001,P=0.002）.After 12 months,there was no statistically significant difference in the increase of CD4^＋T lymphocyte between the two groups （P=0.061,P=0.219,P=0.738）.After the antiviral therapy,there was no significant difference in CD8^＋T lymphocyte count between the two groups at all stages （P=0.447,P=0.681,P=0.639,P=0.464,P=0.886,P=0.712）.Conclusion：The immunological reconstitution of the AIDS patients were directly effected by CD4^＋T lymphocyte baseline,and the CD8＋T lymphocyte count recovery was relatively slow.

关 键 词：高效抗逆转录病毒治疗 艾滋病 免疫重建 CD4^+T淋巴细胞 

分 类 号：R512.91[医药卫生—内科学] R511[医药卫生—临床医学]