CAMSAP3-ACF7复合体通过结合非中心体微管和微丝纤维协同调节其动态性  

The CAMSAP3-ACF7 Complex Couples Noncentrosomal Microtubules with Actin Filaments to Coordinate Their Dynamics

作　　者：Wenxiu Ning Yanan Yu Honglin Xu Xiaofei Liu Daiwei Wang Jing Wang Yingchun Wang 孟文翔 

机构地区：[1]不详 [2]中国科学院遗传与发育生物学研究所

出　　处：《科学新闻》2017年第4期110-110,共1页Science News

基　　金：国家自然科学基金;973计划;中国科学院重点部署项目的支持

摘　　要：为了适应各种复杂的细胞功能，细胞骨架网络的动态性是必需的。细胞骨架的主要成分有两类，即微管和微丝纤维，它们彼此结合形成了复杂精细的网络，从而为其细胞功能提供物理基础。但到目前为止，对于二者精缃的协同作用背后的分子机制仍知之甚少。For adaptation to complex cellular functions, dynamic cytoskeletal networks are required. There are two major components of the cytoskeleton, microtubules and actin filaments, which form an intricate network maintaining an exquisite cooperation to build the physical basis for their cellular function. However, little is known about the molecular mechanism underlying their synergism. Here, we show that in Caco2 epithelial cells, noncentrosomal microtubules crosstalk with F-actin through their minus ends and contribute to the regulation of focal adhesion size and cell migration. We demonstrate that ACF7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with Nezha (also called CAMSAP3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. Those noncentrosomal microtubules cooperate with actin filaments through retrograde flow to keep their length and orientation perpendicular to the cell edge as well as regulate focal adhesion size and cell migration.

关 键 词：协同作用 动态性 纤维 复合体 细胞骨架 心体 物理基础 分子机制 

分 类 号：G804.21[文化科学—运动人体科学]