肠上皮受体LRRC19促进招募免疫细胞及肠道炎症  

The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation

作　　者：Shuisong Cao Xiaomin Su Benhua Zeng Hui Yan Yugang Huang Enlin Wang Huan Yun Yuan Zhang Feifei Liu Wenxia Li Hong Wei Yongzhe Che 杨荣存[2,3] 

机构地区：[1]不详 [2]南开大学医学院 [3]中国免疫学会基础分会

出　　处：《科学新闻》2017年第4期133-133,共1页Science News

摘　　要：哺乳动物胃肠道有大量和多样化的共生菌。近年来的研究逐渐表明，人类健康高度依赖于肠道其生菌对免疫的贡献。Commensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and maintain gut immune responses is largely unknown. Here, we have found that the gut immune receptor leucine-rich repeat (LRR) C19 is involved in host-microbiota interactions. LRRC19 deficiency not only impairs the gut immune system but also reduces inflammatory responses in gut tissues. We demonstrate that the LRRC19-associated chemokines CCL6, CCL9, CXCL9, and CXCL10 play a critical role in immune cell recruitment and intestinal inflammation. The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas. We also found that the expression of REGs may be regulated by gut Lactobacillus through LRRC19-mediated activation of NF-κB. Therefore, our study establishes a regulatory axis of LRRC19, REGs, altered microbiotas, and chemokines for the recruitment of immune cells and the regulation of intestinal inflammation.

关 键 词：免疫细胞 炎症 招募 受体 哺乳动物 人类健康 多样化 

分 类 号：Q516[生物学—生物化学]