大脑皮层内兴奋性突触传递的短时程可塑性特异地成熟于“关键期”开启阶段  

Selective Maturation of Temporal Dynamics of Intracortical Excitatory Transmission at the Critical Period Onset

作　　者：Qinglong Miao Li Yao Malte J.Rasch Qian Ye Xiang Li 章晓辉 

机构地区：[1]不详 [2]北京师范大学认知神经科学与学习国家重点实验室 [3]中科院神经科学研究所

出　　处：《科学新闻》2017年第4期155-155,共1页Science News

基　　金：科技部973项目的资助

摘　　要：在个体出生后的大脑发育“关键期”阶段，神经细胞连接的功能和结构在经验指导下发生急剧的修剪和优化。其中抑制性突触传递的发育成熟是调控“关键期”开启的关键因素，但对其开启的突触环路机制仍所知甚少。Although the developmental maturation of cortical inhibitory synapses is known to be a critical factor in gating the onset of critical period (CP) for experience-dependent cortical plasticity, how synaptic transmission dynamics of other cortical synapses are regulated during the transition to CP remains unknown. Here, by systematically examining various intracortical synapses within layer 4 of the mouse visual cortex, we demonstrate that synaptic temporal dynamics of intracortical excitatory synapses on principal cells (PCs) and inhibitory parvalbuminor somatostatin-expressing cells are selectively regulated before the CP onset, whereas those of intracortical inhibitory synapses and long-range thalamocortical excitatory synapses remain unchanged. This selective maturation of synaptic dynamics results from a ubiquitous reduction of presynaptic release and is dependent on visual experience. These findings provide an additional essential circuit mechanism for regulating CP timing in the developing visual cortex.

关 键 词：突触 大脑皮层 成熟 可塑性 兴奋性 大脑发育 神经细胞 

分 类 号：Q421[生物学—神经生物学]