PKCι／λ和PKMζ在海马长时程增强和记忆的起始与维持阶段发挥不同作用  

Distinct Roles of PKCι/λ and PKMζ in the Initiation and Maintenance of Hippocampal Long-Term Potentiation and Memory

作　　者：Shaoli Wang Tao Sheng Siqiang Ren Tian Tian 陆巍 

机构地区：[1]不详 [2]东南大学生命科学研究院

出　　处：《科学新闻》2017年第4期157-157,共1页Science News

基　　金：国家自然科学基金;科技部973项目的资助

摘　　要：PKMζ曾被认为在长时程增强（一种学习记忆的细胞模型）和记忆的维持阶段起重要作用，但近几年在PKMζ敲除动物方面的研究对这个观点提出严重挑战，而非典型PKC的另一个亚型PKCι/λ逐渐成为一个潜在的替代者而发挥作用。Summary PKMζ has been proposed to be essential for maintenance of long-term potentiation (LTP) and long-term memory (LTM). However, recent data from PKMζ-knockout mice has called this role into question. Instead, the other atypical isoform, protein kinase C iota/lambda (PKCι/λ), has emerged as a potential alternative player. Therefore, the nature of the “memory molecule” maintaining learned information remains uncertain. Here, we report knockdown (KD) of PKCι/λ and PKMζ in the dorsal hippocampus and find deficits in early expression and late maintenance, respectively, during both LTP and hippocampus-dependent LTM. Sequential increases in the active form of PKCι/λ and PKMζ are detected during LTP or fear conditioning. Importantly, PKMζ, but not PKCι/λ, KD disrupts previously established LTM. Thus, PKCι/λ and PKMζ have distinct functions in LTP and memory, with PKMζ playing a specific role in memory maintenance. This relaying pattern may represent a precise molecular mechanism by which atypical PKCs regulate the different stages of memory.

关 键 词：长时程增强 学习记忆 PKM 海马 非典型 细胞 动物 

分 类 号：Q427[生物学—神经生物学]