100例新疆地区原发性胆汁肝硬化临床分析  

Clinical analysis about 100 cases of primary biliary cirrhosis in Xinjiang region

作　　者：赵慧[1] 王亮[1] 王倩[1] 李慧君[1] 罗德梅[1] 

机构地区：[1]新疆医科大学第一附属医院,乌鲁木齐830054

出　　处：《新疆医学》2017年第3期242-244,233,共4页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区自然科学基金(2014211C047)

摘　　要：目的通过分析新疆地区PBC患者的临床特点,可为今后诊治提供研究基础。方法回顾性分析100例新疆地区PBC患者的临床症状、体征和实验室检测资料。结果 1)分析临床特点发现,新疆地区PBC患者明显具有乏力、黄疸和皮肤瘙痒三大症状;(2)与对照组相比,100例新疆地区PBC患者常规生化检测血清中ALT、AST、ALP、GGT、TBIL、DBIL、TBA、5-NT水平均显著升高(P<0.01),PA、ALB、GLO、CHE水平显著降低(P<0.01);血清中HA、LN、CIV、PIIINP水平显著升高(P<0.01);(3)自身抗体检测发现,100例新疆地区PBC患者以ANA和AMA为主。ANA阳性中以1:1000滴度为主,其次为1:320滴度。荧光模型以颗粒型为主,其次为着丝点型。结论高滴度ANA阳性结果对新疆地区PBC患者诊断具有重要价值,另自身抗体检测结合其他实验室检查和临床特点,可提高PBC的诊断率,为患者早期治疗提供帮助。Objective Through analysis about the clinical characteristics of patients with PBC, to provide the basis for diagnosis and treatment of this disease in the filture. Methods Clinical and experimental data among 100 patients in Xinjiang were analyzed retrospectively. Results （1）PBC patients in Xinjiang were found to get obviously weakness, jaundice and skin itching according to clinical characteristics of patients ; （2） Routine biochemical results showed that the levels ofALT, AST, ALP, GGT, TBIL, DBIL and 5-NT among 100 cases with PBC in Xinjiang were significantly higher than those in control group （P 〈 0.01 ）, while the levels of PA, GLO, CHE awere significantly reduced in 100 cases with PBC （P 〈 0.01 ）; The levels of HA, LN, CIV, PIIINP in serum in PBC patients increased significantly compared with those in control group（P 〈 0.01 ）. （3） Auto-antibody testing showed that 100 patients with PBC in Xinjiang were mainly ANA and AMA type. Among ANA positive patients , 1：1000 degree was the most type, the second type was 1：320 degree. Fluorescence model was mainly particle type , and silk point type. Conclusion High titer ANA positive results have an important value for diagnosis of PBC patients in Xinjiang area. , It can help diagnosis of PBC and provide help for the early treatment of patients if it is combined with other laboratory tests and clinical features.

关 键 词：新疆 原发性胆汁肝硬化 临床分析 

分 类 号：R446[医药卫生—诊断学]