黄芩解热抗炎作用有效组分筛选的研究  

Study on screening of effective parts of scutellariabaicalensis antipyretic and anti-inflammatory

作　　者：王洪玉[1] 苑艺蕾 陈平平[1] 汪娜[1] 刘树民[1,2] 

机构地区：[1]黑龙江中医药大学药学院,哈尔滨150040 [2]教育部北药基础与应用研究重点实验室,哈尔滨150040

出　　处：《哈尔滨商业大学学报（自然科学版）》2016年第5期542-545,共4页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金：国家重点基础研究发展计划"973计划"(2013CB531804);黑龙江省高等学校科技创新团队-研究方向中药药性理论研究

摘　　要：为筛选出黄芩具有解热抗炎作用的有效组分,采用苯酚和干酵母致热法制造大白鼠发热模型,采用二甲苯致耳廓肿胀法制造小鼠急性炎症模型,观察黄芩及黄芩苷类、黄芩苷元类、多糖及黄芩高低剂量组对大鼠发热模型、小鼠炎性模型的解热、抗炎作用;对干酵母、苯酚所致大鼠发热的影响;对小鼠耳肿胀的抗炎作用等.结果表明,黄芩及其有效组分均有不同程度的解热、抗炎作用,有防止体温升高和消除炎症的作用,其中尤以黄芩高剂量组、黄芩苷类和黄芩苷元类最为明显,黄芩多糖组分无显著性作用,黄芩及其有效组分与空白对照组比较差异有统计学意义(P<0.05).黄芩具有很好的解热、抗炎作用,但其作用强度与组分间的差异和剂量的大小有关,且随剂量升高,黄芩的解热抗炎作用越明显.To screen the effective components that have anti- inflammatory and antipyretic effect of scutellariabaicalensis,the heat generation model of rats was made by the method of phenol and dry yeast. The inflammation model of mice was induced by xylene induced ear edema. The effects of baicalin and its components on rat fever model andmice model of inflammatory,antipyretic and anti- inflammatory action were observed. Results showed that scutellariabaicalensis and its effective components haddifferent degrees of antipyretic and anti- inflammatory effects,andprevented and eliminated the role of inflammation in body temperature. Especially in the high dose group,scutellariabaicalin and baicalinmetaclasswas the most obvious. Scutellaria polysaccharides had no significant effect. Scutellariabaicalensis and its effective componentshad significant effect（ P〈 0. 05） compared with the control group.Scutellariabaicalensis has good antipyretic and anti- inflammatory action,but the size of the strength of effect and group differences and dose related and increased with the dose,the antipyretic and anti- inflammatory effects of scutellariabaicalensisare more obvious.

关 键 词：黄芩 解热 抗炎 有效组分 动物实验 

分 类 号：R285[医药卫生—中药学]