727例银杏达莫注射液不良反应报告分析  

Analysis of 727 ADR Reports of Tinkgo Leaf Extract and Dipyridamole Injection

作　　者：李虹霞[1] 徐美玲[2] 马开兰[3] 王科[4] 

机构地区：[1]重庆市急救医疗中心保健科,重庆400014 [2]重庆市急救医疗中心药剂科,重庆400014 [3]重庆市急救医疗中心创伤科,重庆400014 [4]重庆市急救医疗中心重症监护病房,重庆400014

出　　处：《中国药房》2017年第14期1931-1933,共3页China Pharmacy

摘　　要：目的:了解银杏达莫注射液不良反应(ADR)发生的特点和一般规律,为临床合理用药提供参考。方法:以"银杏达莫注射液""不良反应"为主题词,检索中国学术期刊全文数据库2005年1月1日-2016年6月28日收载的期刊文献,对患者性别、年龄、原患疾病、过敏史、用药情况、ADR发生时间、累及器官/系统及临床表现等进行统计、分析。结果:检索得到有效文献14篇,共计727例患者。其中,女性多于男性(57.63%vs.42.37%),年龄多在50岁以上,原患疾病以血栓栓塞性疾病、冠心病为主;ADR多在用药30 min内发生(268例,36.86%);累及器官/系统以神经系统(254例,28.60%)、皮肤及其附件(228例,25.68%)和消化系统(187例,21.06%)为主,严重者可致过敏性休克;新的严重的ADR 18例(2.48%);所有ADR均好转,无死亡病例。结论:临床应严格掌握银杏达莫注射液的适应证,辨证施治、合理用药,对用药过程严密观察,警惕ADR的发生。OBJECTIVE： To investigate the characteristics and general rule of ADR induced by Ginkgo leaf extract and dipyri- damole injection, and to provide reference for clinical rational drug use. METHODS： Using ＂Ginkgo leaf extract and dipyridamole injection ADR＂ as subject, the journal articles were retrieved from CJFD during Jan. 1st, 2005-Jun. 28th, 2016, and then ana- lyzed statistically in respects of gender, age, primary disease, allergic disease, drug use, occurrence time of ADR, organs/systems involved and clinical manifestations. RESULTS： A total of 14 valid articles had been collected, involving 727 patients in total. Meanwhile, female was more than male （57.63% vs. 42.37% ） and most of them aged more than 50 years; primary diseases were mainly thromboembolic disease and coronary heart disease; most of ADR happened within 30 min after medication （268 cases, 36.86% ）. Organs/systems involved in ADR were mainly nervous system （254 cases, 28.60% ）, followed by skin and its appen- dants （228 cases, 25.68%）, digestive system （187 cases, 21.06%）; severe ADR could cause anaphylactic shock. There were 18 cases of new severe ADR （2.48%） ; all ADR cases were recovered, and no death occurred. CONCLUSIONS： It is suggested to strictly control indications, differential diagnosis and treatment, rational drug use, close monitoring through the whole process, maintain a high level of awareness to ADR.

关 键 词：银杏达莫注射液 药品不良反应 文献分析 

分 类 号：R969.3[医药卫生—药理学]