养阴益气合剂治疗特发性肺间质纤维化气阴两虚证临床观察  

Clinical Observation of Yangyin Yiqi Mixture for IPF with Qi-yin Deficiency Syndrome

作　　者：谢银光 童钟 

机构地区：[1]广宁县中医院,广东广宁526300

出　　处：《新中医》2017年第5期38-40,共3页New Chinese Medicine

基　　金：广东省中医药局科研课题(20141212)

摘　　要：目的:观察养阴益气合剂治疗特发性肺间质纤维化(IPF)气阴两虚证的临床疗效,及对患者生活质量、运动能力及肺功能的影响。方法:选取90例IPF气阴两虚证患者,按照随机数字表法分为观察组和对照组各45例。对照组给予醋酸地塞米松片治疗,观察组给予养阴益气合剂治疗。观察2组治疗前后圣乔治呼吸问卷(SGRQ)评分、6 min步行试验距离、肺功能及中医症状积分的变化,并对治疗总有效率进行对比分析。结果:治疗后,2组6 min步行试验距离均较治疗前延长(P<0.05);观察组的SGRQ评分低于对照组和同组治疗前(P<0.05),6 min步行试验距离长于对照组(P<0.05)。治疗后,2组第1秒用力呼气容积(FEV_1)均较治疗前增加(P<0.05),观察组的FEV_1在预计值中百分比(FEV_1%)和FEV_1/用力肺活量(FVC)均较治疗前上升(P<0.05);观察组的FEV_1大于对照组(P<0.05),FEV_1%和FEV_1/FVC均高于对照组(P<0.05)。治疗后,对照组的汗出、舌苔、脉象积分及观察组的气喘、咳嗽等7项中医症状积分均较治疗前降低(P<0.05);观察组的7项中医症状积分均低于对照组(P<0.05)。对照组治疗总有效率62.22%,观察组治疗总有效率88.89%,2组比较,差异有统计学意义(P<0.01)。结论:养阴益气合剂治疗IPF气阴两虚证,能提高患者的生活质量,增强运动能力,改善临床症状和肺功能,疗效优于醋酸地塞米松片。Objective：To observe the clinical effect of Yangyin Yiqi mixture for idiopathic pulmonary fibrosis（IPF） with Qi-yin deficiency syndrome, and its effect on quality of life, sports ability and pulmonary function of patients. Methods ：Selected 90 patients with IPF with Qi-yin deficiency syndrome,and divided them into the observation group and the control group of 45 cases in each with random table method.The control group was given the therapy of dexamethasone acetate tablets,and the observation group was given the therapy of Yangyin Yiqi mixture. Observed change of St George＇s respiratory questionnaire（SGRQ） score,6 minutes walk test distance,pulmonary function and Chinese medicine symptom score of the two groups before and after treatment,and made contrastive analysis of the total effective rates. Results：After treatment,6minutes walk test distance of the two groups was prolonged（P〈0.05）,6 minutes walk test distance of the observation group was longer than that of the control group（P〈0.05）. After treatment,SGRQ scores of the observation group were lower than those of the control group and the scores of the observation group before treatment（P〈0.05）. After treatment, comparing with that before treatment,forced expiratory volume in one second（FEV_1） of the two group was increased.The ration of FEV_1 to predicated value（FEV_1%） and the ration to FEV_1 in forced Vital capacity（FVC） of the observation group were higher than those before treatment（P〈0.05）,and the FEV_1,FEV_1% and FEV_1/FVC of the observation group were higher than those of the control group（P〈0.05）. After treatment, scores of sweat, tongue and pulse of the control group and asthma, cough and other Chinese medicine symptom scores of the observation group were lower than those before treatment（P〈0.05）. The seven Chinese medicine symptom scores of the observation group were lower than those of the control group（P〈0.05）. The total effective rate was 62.22% in the control group and was 88.

关 键 词：特发性肺间质纤维化(IPF) 气阴两虚证 养阴益气合剂 醋酸地塞米松片 生活质量 运动能力 肺功能 

分 类 号：R563[医药卫生—呼吸系统]