补肾健脾方联合肾康注射液对慢性肾功能衰竭患者肾功能及氧化应激状态的影响  

Effect of Bushen Jianpi Prescription Combined with Shenkang Injection on Renal Function and Oxidative Stress State in Patients with Chronic Renal Failure

作　　者：于绣红[1] 

机构地区：[1]丹东市中心医院肾内科,辽宁丹东118000

出　　处：《新中医》2017年第5期50-53,共4页New Chinese Medicine

摘　　要：目的:观察补肾健脾方联合肾康注射液对慢性肾功能衰竭患者肾功能及氧化应激状态的影响。方法:选取140例慢性肾功能衰竭湿浊内蕴、脾肾气虚证患者,按照随机数字表法分为对照组和观察组各70例,对照组采用肾康注射液治疗,观察组采用补肾健脾方联合肾康注射液治疗,比较2组患者的临床疗效及24 h尿蛋白定量、肾小球滤过率(GFR)、尿素氮(BUN)、内生肌酐清除率(CCr)、肌酐(SCr)等肾功能指标治疗前后的数值变化,并检测2组患者治疗前后的血清丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、还原型谷胱甘肽(GSH)、超氧化物歧化酶(SOD)水平。结果:观察组总有效率为91.43%,对照组总有效率为78.57%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组24 h尿蛋白定量、BUN、SCr、MDA水平均低于治疗前(P<0.05),观察组以上4项指标值均低于对照组(P<0.05);2组GFR、CCr、GSH-Px、GSH、SOD水平与治疗前比较均升高(P<0.05),观察组5项指标值均高于对照组(P<0.05)。结论:慢性肾功能衰竭患者存在明显的氧化应激状态,采用补肾健脾方联合肾康注射液治疗,具有良好的临床疗效,能有效清除体内的氧自由基、提高机体的抗氧化活性,并能有效改善患者的肾功能。Objective：To observe the clinical effect of Bushen Jianpi prescription combined with Shenkang injection on renal function and oxidative stress state in patients with chronic renal failure. Methods：Selected 140 chronic renal failure patients with syndrome of accumulation endogenous pathogenic dampness and deficiency of vital energy of spleen and kidney,and divided them into the control group and the observation group with 70 cases in each,according to the random table method. The control group was given Shenkang injection, and the observation group was given Bushen Jianpi prescription combined with Shenkang injection. Compared value variation of clinical curative effect,24 hours urinary protein excretion, glomerular filtration rate（GFR）, blood urea nitrogen（BUN）, endogenous creatinine clearance（CCr）, serum creatinine（SCr） of the two groups before and after treatment, and detected levels of serum malondialdehyde（MDA）,glutathione peroxidase（GSH-Px）,reduced glutathione（GSH） and total superoxide dismutase（SOD）. Results：The total effective rate was 91.43% in the observation group,and was 78.57% in the control group,the difference being significant（P〈0.05）.After treatment,24 hours urinary protein excretion,and levels of BUN,SCr and MDA of the two groups were all lower than those before treatment（P〈0.05）,and the four indexes of the observation group were all lower than those of the control group.Levels of GFR,CCr,GSH-Px,GSH and SOD of the two groups were all higher than those before treatment（P〈0.05）,and indexes of the observation group were all higher than those of the control group（P〈0.05）. Conclusion：There is obvious oxidative stress state in chronic renal failure patients. The combination usage of Bushen Jianpi prescription and Shenkang injection has good clinical efficacy,can effectively scavenge oxygen free radicals in the body,and improve the antioxidant activity and renal function of patients.

关 键 词：慢性肾功能衰竭 脾肾气虚证 肾康注射液 补肾健脾方 肾功能 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]