吡咯烷类有机小分子催化合成1,4-二氢吡啶衍生物  

Synthesis of 1,4-Dihydropyridine Derivatives Catalyzed by Pyrrolidine Organic Small Molecules

作　　者：裴学海 黄克俊 尹晓刚[1] 陈治明[1] 

机构地区：[1]贵州师范大学化学与材料科学学院贵州省功能材料化学重点实验室,贵阳550001

出　　处：《化学通报》2017年第5期477-481,共5页Chemistry

基　　金：国家自然科学基金项目(21362006);贵州省自然科学基金项目(黔科合J字[2009]2021)资助

摘　　要：对以芳香醛、乙酰丙酮及碳酸氢铵为原料,苯甲酰胺吡咯烷为催化剂,合成1,4-二氢吡啶的反应进行了研究。考察了催化剂、溶剂、温度、时间和氮源对产率的影响。结果表明,反应温度70℃,芳香醛、乙酰丙酮和碳酸氢铵的摩尔比0.5∶1∶0.5,催化剂Ⅳ的用量10(mol)%时,产率最高,可达93%。催化剂循环使用3次,产率基本不变。该反应具有催化剂经济易得、反应条件温和、环境友好和操作简单等优点。Synthesis of 1, 4-dihydropyridine derivatives catalyzed by （R）-Pyrrolidin-2-yl-methanamine derivatives was developed using aromatic aldehydes, acetacetic ester and ammonium bicarbonate as starting materials. The effects of the reaction temperature, reaction time, solvent, catalyst and nitrogen source on the yield were investigated. The optimal conditions were as followed, the reaction temperature is 70℃ , the molar ratio of aromatic aldehydes, acetacetic ester and ammonium bicarbonate is 0. 5： 1.0： 0. 5, the amount of catalyst is 10 （tool） %. Under these conditions, the highest yield of 1,4-dihydropyridines reached up to 93%. It was also observed that the catalyst could be recycled three times without obvious loss in catalytic activity. The procedure has the advantages of inexpensive catalyst, mild reaction condition, environmentally benign and simplicity.

关 键 词：吡咯烷衍生物 1  4-二氢吡啶衍生物Hantzsch反应 循环催化 

分 类 号：O621.251[理学—有机化学] O626.32[理学—化学]