长循环脂质体递送系统在肿瘤诊断和治疗中的应用  

Long Circulating Liposomes Delivery System in Diagnosis and Treatment of Tumor

作　　者：张亮[1] 

机构地区：[1]美国霍华德大学纳米药物研究中心,华盛顿20059

出　　处：《医药导报》2017年第5期463-468,共6页Herald of Medicine

摘　　要：随着现代医学和药学的飞速发展,对肿瘤的诊断和治疗已取得了长足的进步。然而,肿瘤治疗依然是临床上一个棘手和亟待解决的问题。因为很多肿瘤早期难以检测,药物治疗毒副作用大,并且疗效差。基于纳米医学背景的长循环脂质体递送系统应用于肿瘤的诊断和治疗,给肿瘤患者带来了新的希望。该脂质体制剂可延长荷载药物或探针在体内的循环时间,增加在肿瘤部位的靶向聚集,提高诊断和治疗效果,并降低由荷载药物或探针引起的毒副作用。该文主要就长循环脂质体递送系统荷载诊断探针或抗肿瘤药物在肿瘤靶向诊断和治疗中的研究进展作简要综述。With the rapid development of modern medicine and pharmacy, the diagnosis and treatment of cancer have made great progress.However, cancer treatment is still a difficult and urgent problem in clinic, because the early detection is difficult for many tumors, the toxic and side effects are serious for drug therapy and treatment effect is poor.Long circulating liposomes delivery system based on nano-medicine are used for the diagnosis and treatment of tumors, which have brought new hope to cancer patients.After administration, long circulating liposomes are known for prolonging the circulation time, increasing the targeting accumulation in tumor, improving the effects of diagnosis and treatment and reducing the toxic and side effects of loading medicine or probe.In this paper, the advantages of long circulating liposome delivery system loaded with diagnostic probe or antitumor agent in targeting diagnosis and treatment of tumor are reviewed.

关 键 词：脂质体 长循环 靶向诊断 肿瘤治疗 

分 类 号：R979.1[医药卫生—药品] R944[医药卫生—药学]