米诺环素对精神分裂症阴性症状的疗效及肿瘤坏死因子-α的影响  

Effect of Minocycline on Negative Symptoms in Patients with Schizophrenia and its Influence on Tumor Necrosis Factor-α

作　　者：宋光明[1] 李建华[1] 

机构地区：[1]浙江省湖州市第三人民医院精神科,湖州313000

出　　处：《医药导报》2017年第5期529-531,共3页Herald of Medicine

摘　　要：目的探讨米诺环素辅助治疗精神分裂症阴性症状的疗效及其对肿瘤坏死因子(TNF-α)的影响。方法精神分裂症患者75例,随机分为治疗组38例,对照组37例。两组均使用奥氮平作为基础治疗用药。治疗组同时加用米诺环素胶囊200 mg·d^(-1),po,bid。治疗周期为12周。在治疗前及治疗12周末分别进行阳性与阴性症状量表(PANSS)、阴性症状量表(SANS)评定及TNF-α检测。结果治疗12周末,治疗组SANS总分及PANSS总分的减分数高于对照组(P<0.05);治疗组和对照组TNF-α水平分别为(6.5±1.3),(7.6±1.8)pg·mL^(-1),治疗组TNF-α水平较对照组下降更明显(P<0.01)。结论米诺环素能有效改善精神分裂症患者的阴性症状,其作用机制可能与降低TNF-α水平有关。Objective To explore the improvement of minocycline on negative symptoms in patients with schizophrenia and its influence on tumor necrosis factor （TNF）-α.Methods Patients with schizophrenia were randomly assigned into two groups.One was olanzapine combined with placebo group （control group, 37 cases）.The other was olanzapine combined with minocycline group （treatment group, 200 mg ·d-1,po,bid, 38 cases）.Both groups were assessed by the positive and negative syndrome scale （PANSS）, the scale for the assessment of negative symptoms （SANS）, and also tested the level of TNF-α before and after 12 weeks treatments.Results After 12 weeks treatments, the scores of SANS and PANSS in treatment group were significantly lower than those of control group （P〈0.05）.The level of TNF-α in treatment group[（6.5±1.3） pg ·mL-1]was significantly lower than that of control group[（7.6±1.8） pg ·mL-1] （P〈0.01）.Conclusion Minocycline can improve negative symptoms in patients with schizophrenia, and the mechanism may be related to lower the level of TNF-α.

关 键 词：米诺环素 精神分裂症 阴性症状 肿瘤坏死因子-Α 

分 类 号：R971.41[医药卫生—药品] R749.3[医药卫生—药学]