HAART联合康爱保生丸对HIV-1病毒载量被有效抑制后的126例艾滋病患者的T淋巴细胞影响的临床观察  

Investigating the T lymphocyte subgroups of 126 HIV/AIDS by HAART plus Kangai Baosheng pill

作　　者：温敏[1] 李艳萍[2] 和丽生[2] 何鹏[3] 江涛[3] 任体莲 

机构地区：[1]云南民族大学民族医药学院,云南昆明650504 [2]云南省中医中药研究院,云南昆明650223 [3]云南省腾冲县人民医院,679100 [4]云南省祥云县人民医院,672100

出　　处：《时珍国医国药》2017年第4期898-900,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金地区科学基金项目(No.81360690)

摘　　要：目的观察HAART联合康爱保生丸治疗对艾滋病患者T淋巴细胞数量的影响。方法对126名HIV-1病毒载量被有效抑制(HIV-1 RNA<100拷贝/ml)的艾滋病患者随机双盲分组,分别给予HAART联合康爱保生丸和HAART+安慰剂,考察12个月T细胞亚群数量的变化;以入组时CD_4^+T细胞基线分层考察两种治疗方法对CD_4^+T细胞的干预作用。结果各时间点两组的T细胞亚群的绝对计数的差异无显著性意义(P>0.05);12月时HAART联合康爱保生丸能显著提高CD_4^+T细胞基线<200个/μl的艾滋病患者的CD_4^+T绝对数量(P=0.015)。结论 HAART联合康爱保生丸可能将持续提高HIV-1病毒载量被有效抑制但CD_4^+T增长缓慢的艾滋病患者的CD_4^+T细胞数量,其作用机制有待进一步研究。Objective To explore the ixffluence of T lymphocyte subgroup of 126 HIV/AIDS by HAART plus Kangai Baosheng pill. Methods Randomized, double - blind, placebo - controlled study was carried on. 126 HIV/AIDS with HIV - 1 RNA suppressed under detection threshold divided by HAART ＋ placebo group and the HAART plus TCM （ Kangai Bao shengeoncen- trated pill） group, the T lymphocyte subgroups were examined during 12 months. The CD4 ＋T absolute counts of two groups di- vided by CD4＋ T cells baseline were investigated. Results There was no significant difference of the T cell subsets counts between the two groups at all time points （ P 〉 0.05 ）. But, after 12 months, CD4＋ T absolute counts of HIV/AIDS individuals with CD4＋T cells baseline 〈 200cells/p.1 treated by HAART combined with Kangai Baosheng pill were higher than HAART ＋ placebo group （P = 0. 015）. Conclusion The advantages of HAART combined with Kangai Baosheng pill was that CD4＋T counts could be ef- fectively increased .

关 键 词：艾滋病 HAART 康爱保生丸 T细胞 CD4+T细胞 HIV-1 RNA 

分 类 号：R285.6[医药卫生—中药学]