参附注射液对重度烧伤患者早期心肌损害的保护作用研究  

Protective effect of Shenfu Injection on early myocardial injury in patients with severe burn

作　　者：李巍[1,2] 陈博[2] 岑瑛[1] 

机构地区：[1]四川大学华西医院整形烧伤科,四川成都610041 [2]四川省医学科学院.四川省人民医院烧伤科,四川成都610072

出　　处：《西部医学》2017年第5期694-697,共4页Medical Journal of West China

基　　金：四川省科技厅科研课题(2014SZ0011)

摘　　要：目的观察参附注射液对重度烧伤患者早期心肌损害的防治作用,并探讨其可能的机制。方法将2014年2月~2016年2月收治的烧伤后24小时内入院的38例烧伤总面积≥50%的患者随机分为治疗组和对照组,每组各19例。两组患者入院后均进行常规治疗,治疗组在对照组治疗基础上将100mL参附注射液加入250ml 5%葡萄糖注射液中进行静脉滴注,每日1次,连用7天。于两组患者伤后1、3、5、7天分别抽取患者静脉血,检测其血浆中心肌高敏肌钙蛋白I(hscTnI)、肌酸激酶同工酶(CK-MB)以及B型脑钠肽(BNP)水平,以公认的各指标正常值作参考。并对3项指标进行相关性分析。结果两组患者各时相点hscTnI、CK-MB、BNP检测值均高于正常值,两组比较,治疗组指标偏低,大部分时相点差异有统计学意义(P<0.05或P<0.01)。伤后24h,两组患者上述指标水平大部分均处于峰值,伤后5天,两组患者上述指标水平均逐渐下降。结论重度烧伤后早期应用参附注射液,可以有效减轻患者心肌细胞损害,对心肌有较好的保护作用。Objective To observe the protective effects of Shenfu Injection on early myocardial damage in patients with severe burn and explore its possible mechanism. Methods 38 burns patients with a total area of more than or equal to 50% TB- SA admitted to hospital within 24 hours after injured were randomly divided into treatment group and control group. The treatment group and control group were treated with routine treatment. The treatment group was treated with Shenfu Injection, additionally. The hscTnI, CK-MB and BNP were observed. Results The hscTnI, CK-MB and BNP in the two groups were high than normal value. The hscTnI, CK-MB and BNP in treatment group were lower than that in control group （P〈0. 05）. The hscTnI, CK-MB and BNP reached the peak 24h after injury and decreased 5 days after injury. Conclusion Shenfu Injection in the early stage of severe burn can effectively reduce the damage of myocardial cells and plays a role in protecting the myocardium.

关 键 词：参附注射液 烧伤 心肌损伤 心肌高敏肌钙蛋白I 肌酸激酶同工酶 B型脑钠肽 

分 类 号：R644[医药卫生—外科学]