含碳酸根羟基磷灰石剂量计材料性能稳定性的实验研究  

Stability of carbonate hydroxyapatite dosimeter material

作　　者：马蕾[1] 刘晔[1] 丛建波[1] 纪云龙[1] 董国福[1] 郭俊旺[1] 吴可[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京市放射生物学重点实验室(No.BZ0325),北京100850

出　　处：《军事医学》2017年第4期278-281,共4页Military Medical Sciences

基　　金：国家自然科学基金资助项目(31670862)

摘　　要：目的研究含碳酸根羟基磷灰石(CHAP)材料的剂量学性能在不同环境条件下的稳定性。方法采用定型压片技术制备剂量计样品,样品经60Coγ线辐照后分别贮存于不同温度、湿度和不同光照背景条件下,采用电子自旋共振(ESR)技术定量分析辐射诱发的自由基。结果在实验观测的3个月内,样品在4℃或室温下保存,信号变化均<3%;40℃保存时,信号变化约13%;室温下当湿度<36%时,信号变化<2%;湿度为76%的高湿度组,信号变化约8%;但高温高湿条件下信号强度并未明显衰减。样品在室温下避光存放1年以上,其信号变化<4.8%。平均照度1600 lux条件下,信号变化<3.8%;在避光条件下,信号变化<3.4%。结论在室温自然环境条件下,该剂量计材料剂量学性能变化不明显,即使较强光照对自由基信号的影响也不显著,长期储存未见信号明显衰减,但高温或高湿环境对样品的测量过程有一定影响,在未来应用中应予以考虑。Objective To develop a promising type of radiation dosimeter based on doped hydroxyapatite,and to study the stability of dosimetric characteristics indepth.Methods The samples prepared by stereotyping techniques were stored under different temperatures,humidity and illumination conditions after60 Co γ-ray irradiation.Electron spin resonance（ESR） technique was used to quantitatively measure the radiation-induced free radical signal.Results The signal change was less than 3% when the dosimeter was preserved at 4℃ or room temperature within 3 months in the experiment.At40℃,the signal changed by about 13%,but at room temperature with the humidity less than 36%,the signal changed less than 2%.The change rose to about 8% when humidity was 76%.However,no significant decay of signal strength occurred at relatively high temperatures and under high humidity conditions.When the samples were stored under average illumination of 1600 lux or in a light-resistant container,the signal changes were less than 3.8% or 3.4% respectively.Long-term stability inspection at room temperature suggested a signal change within 4.8%.Conclusion The dosimetric properties of the material don＇ t change significantly below room temperature in a natural environment and exhibit good stability over long-term storage.The free radical signal is not influenced drastically by relatively strong light exposure.However,a high temperature or a highly humid environment may have some effect on the measurement process,which should be taken into consideration in further applications.

关 键 词：羟基磷灰石类 辐射剂量计 稳定性 电子自旋共振 自由基 

分 类 号：R318.08[医药卫生—生物医学工程]