磁共振扩散张量成像评价女性盆底肌加龄性变化规律的可行性研究  

Feasibility of Diffusion Tensor Imaging(DTI) in Evaluating the Age-related Changes of Normal Female Pelvic Floor Muscle

作　　者：门永超 孙成凤[1] 韩雨[1] 刘金刚[1] 常光辉[1] 张桂华[1] 王锡臻[1] 王滨[2] 

机构地区：[1]潍坊医学院附属医院影像中心 [2]滨州医学院影像学研究所

出　　处：《中国医学计算机成像杂志》2017年第2期146-150,共5页Chinese Computed Medical Imaging

基　　金：国家自然科学基金项目(81171303;30470518);山东省自然科学基金(ZR2009CL046;ZR2010HQ029;ZR2013HQ020);山东省优秀中青年科学家科研奖励基金(BS2012YY038);山东省卫生厅科技发展项目(2011WSB29009;2011HW067);滨州医学院山东省特色重点学科;山东省科技攻关项目(2007GG30002032;2008GG30002004);潍坊医学院博士科研启动基金(2009);潍坊医学院大学生科技创新基金(KX2015011)~~

摘　　要：目的:通过分析女性盆底肌磁共振扩散张量成像(DTI)参数值随年龄的变化,探讨DTI评价女性盆底肌加龄性变化规律的可行性。方法:研究对象为42名无盆底功能障碍的女性,行常规磁共振(MRI)和DTI扫描,将DTI原始数据于ADW4.5工作站上进行后处理,分别测量双侧肛提肌及闭孔内肌的表观弥散系数(ADC)、各向异性分数(FA)、容积比各向异性(VRA),分析肛提肌、闭孔内肌的DTI参数值随年龄的变化趋势。结果:青年组、中年组及老年组的肛提肌FA值分别为0.29±0.05,0.33±0.06和0.30±0.06;闭孔内肌的FA值分别为0.33±0.03,0.35±0.03和0.34±0.02。青年组和中年组间的肛提肌和闭孔内肌的FA值差异均有统计学意义(P=0.007,0.026)。各年龄组间肛提肌和闭孔内肌的ADC和VRA均无统计学差异。结论:DTI的参数值FA值与年龄存在关联,DTI可以评价女性盆底肌的加龄性变化规律。Purpose： To explore the feasibility of diffusion tensor imaging （DTI） in evaluating the age-related changes of normal female pelvic floor muscles by analyzing the parameters value changes in different age cohorts. Methods： Forty-two females who had no pelvic dysfunction underwent conventional MR sequences and DTI. The DTI datawere transferred to GE AW4.5 Workstation software for processing. Apparent diffusion coefficient （ADC）, fractional anisotropy （FA） and volume ratio anisotropy （VRA） of levator ani muscle and obturtor internus muscle were recorded. The values ofADC, FA and VRA in every age cohorts were analyzed. Results： The FA values of levator ani muscle in youth group, middle-aged group and old group were 0.29±0.05, 0.33±0.06 and 0.30±0.06, respectively. The FA values of obturtor internus of these three groups were 0.33±0.03, 0.35±0.03 and 0.34±0.02. The FA values of levator ani muscle and obtttrtor internus in youth group were lower than those in middle-aged group. There was no statistical significant difference in ADC value and VRA value between different age cohors. Conclusion： DTI can reflect the age-related changes of normal pelvic floor muscles by analyzing the changes of parameter values in different age cohorts.

关 键 词：盆底肌 磁共振扩散张量成像 表观弥散系数 各向异性分数 容积比各向异性 

分 类 号：R445.2[医药卫生—影像医学与核医学]