西他生坦对体外循环犬肾微循环的影响：超声微泡造影术监测  

Effect of sitaxsentan on renal microcirculation in beagle dogs undergoing cardiopulmonary bypass： mornitoring using ultrasound microbubble angiography

作　　者：白毅平 刘力 唐霓 张亚兵[2] 刘斌[2] 

机构地区：[1]西南医科大学附属医院麻醉科,泸州市646000 [2]四川大学华西医院麻醉科,成都市610000

出　　处：《中华麻醉学杂志》2017年第3期292-295,共4页Chinese Journal of Anesthesiology

基　　金：四川省科技厅科技支撑计划（2012FZ0121）

摘　　要：目的采用超声微泡造影术监测肾微循环，评价西他生坦对体外循环（CPB）犬肾微循环的影响。方法雄性比格犬18只，体重10—15kg，2～4岁，采用随机数字表法分为3组（n=6）：假手术组（Sham组）、CPB组和西他生坦组（S组）。S组于CPB前1h静脉输注西他生坦0．7mg／kg，经30min输注完毕。于CPB前（T1）、CPB1h（T：）、CPB结束（T3）和CPB结束后2h（T4）时采用超声微泡造影术获得肾实质灌注的时间．强度曲线，拟合定量参数：上升支斜率（A）、曲线下面积（AUC）、曲线峰值强度绝对值（DPI）和达峰时间（TTP）。结果与Sham组比较，CPB组T2-4时皮质与髓质A降低，T3,4时AUC和TTP升高，T4时DPt降低，S组T2-4时皮质与髓质A降低，TTP升高，T¨时AUC升高（P〈0．05），DPI差异无统计学意义（P〉0．05）。与CPB组比较，s组T。时皮质与髓质A升高，AUC及TTP降低（P〈0．05），DPI差异无统计学意义（P〉0．05）。结论西他生坦可改善CPB犬肾微循环。Objective To evaluate the effect of sitaxsentan on renal microcirculation in beagle dogs undergoing cardiopulmonary bypass （CPB） when ultrasound microbubble angiography was used to monitor renal microcirculation. Methods Eighteen male Beagle dogs, weighing 10-15 kg, aged 2-4 yr, were allocated into 3 groups （n= 6 each） using a random number table： sham operation group （Sham group）, CPB group and sitaxsentan group （S group）. Sitaxsentan 0.7 mg/kg was infused over 30 min starting from 1 h before CPB in group S. Before CPB （T1）, at 1h ofCPB （T2）, at the end ofCPB （T3） and at 2h after the end of CPB （T4） , the time-intensity curve of renal parenchyma perfusion was obtained using ultrasound microbubble angiography, and quantitative parameters including the slope rate of ascending curve （A）, area under curve （AUC）, derived peak intensity （DPI） and time to peak （TTP） were fitted. Results Compared with Sham group, the value of A was significantly decreased at T2,4, AUC and TTP were increased at T3.4, DPI was decreased at T4 in renal cortex and medulla in CPB group, and the value of A was significantly decreased and TTP was increased at T2-4, AUC was increased at T3.4 （ P〈 0.05）, and no signifieant ehange was found in DPI in renal cortex and medulla in S group （P〉0.05）. Compared with CPB group, the value of A was significantly increased and AUC and TTP were decreased at T3.4 in renal cortex and medulla （P〈0. 05） , and no significant change was found in DPI in renal cortex and medulla in group S （P〉0. 05）. Conclusion dogs undergoing CPB.

关 键 词：肾 微循环 心肺转流术 超声检查 内皮素受体拮抗剂 

分 类 号：R614[医药卫生—麻醉学]