丹红注射液联合硫酸氢氯吡格雷片治疗对急性冠脉综合征患者血清炎性因子、血小板活化及血管内皮功能的影响  

Effect of DanHong injection combined with Clopidogrel hydrogen sulphate tablets on the serum inflammatory factors,platelet activation and vascular endothelium function

作　　者：张晨光 张新岭[2] 张英 

机构地区：[1]山东省巨野县人民医院急诊医学科,山东菏泽274900 [2]山东省济宁市第一人民医院东院区心内二科,山东济宁272000

出　　处：《海南医学院学报》2017年第7期894-897,共4页Journal of Hainan Medical University

基　　金：山东省自然科学基金项目(Y2014C281)~~

摘　　要：目的:采用丹红注射液联合硫酸氢氯吡格雷片治疗急性冠脉综合征,明确联合治疗对急性冠脉综合征患者血清炎性因子,血小板活化水平及血管内皮功能的影响。方法:选取于我院诊治的ACS患者102例作为研究对象,依据数据表法将其分为对照组及观察组,每组各51例。对照组患者采用常规治疗加硫酸氢氯吡格雷片治疗,观察组在对照组的基础上加丹红注射液治疗,共治疗2个月。检测所有患者治疗前后血清炎性因子(IL-6、TNF-α、hs-CRP),血小板活化(sCD40L、CD62p、GPⅡb/Ⅲa受体复合物)水平及血管内皮功能(NO、ET-1和vWF)相关指标水平变化。结果:治疗前两组各项指标比较,差异不显著无统计学意(P>0.05);治疗后,两组的IL-6、TNF-α、hs-CRP、sCD40L、CD62p、GPⅡb/Ⅲa受体复合物、ET-1和vWF水平较治疗前均显著下降,且观察组水平显著低于对照组,差异均具统计学意义(P<0.05);两组治疗后的NO较同组治疗前均显著升高,且观察组显著高于对照组,差异均具统计学意义(P<0.05)。结论:丹红注射液联合硫酸氢氯吡格雷片治疗可有效改善患者炎性因子水平,抑制血小板活化以及改善血管内皮功能,具有一定的临床价值。Objective：To identify the effect of patients with acute coronary syndrome treated by the DanHong injection combined with Clopidogrel hydrogen sulphate tablets on the serum inflammatory factors,the level of platelet activation and the vascular endothelium function.Methods：A total of 102 ACS patients who were admitted in our hospital from December 2014 to April 2016 were selected as the research subjects,and were divided into the control group and observation group according to the data sheet method,each group was composed of 51 cases.The control group was treated with conventional therapy and Clopidogrel hydrogen sulphate tablets and the observation was given DanHong injection additionally on the basis of control group.The treatment period was 2 months.Detected the change level of related indexes of all patients before and after treatment,which contained the serum inflammatory factors（IL-6,TNF-α,hs-CRP）,the level of platelet activation（sCD40L,CD62 p,GPⅡb/Ⅱa receptor compound）,and the vascular endothelium function（NO,ET-1,and vWF）.Results：It was shown that each index of this two groups was no statistical significant（P〉0.05）before treatment.After treatment,the level of IL-6,TNF-α,hs-CRP,sCD40 L,CD62p,GPⅡb/Ⅱa receptor compound,ET-1and vWF were decreased dramatically compared with that before treatment,it was statistical significant difference（P〈0.05）;Moreover,these indexes in the observation group was lower than the control group,there was statistical significant difference between this two groups（P〈0.05）.The NO level of all patients was increased significantly after treatment（P〈0.05）,and the level in observation group was increased more obviously than the control group,the interlock difference was statistical significant（P〈0.05）.Conclusions：It was confirmed that the DanHong injection combined with Clopidogrel hydrogen sulphate tablets could ameliorate the level of serum inflammatory factors effectively,depress the blood platelet activation,and improve the v

关 键 词：急性冠脉综合征患者 丹红注射液 硫酸氢氯吡格雷片 炎性因子 血小板活化 血管内皮功能 

分 类 号：R541[医药卫生—心血管疾病]