法舒地尔注射液辅助手术治疗脑外伤对应激激素及炎症因子的影响  

Effects of fasudil injection on stress hormone and inflammatory factors in the treatment of traumatic brain injury

作　　者：魏小川[1] 熊学辉[1] 罗杰[1] 

机构地区：[1]湖北省黄冈市中心医院神经外科,湖北黄冈438000

出　　处：《海南医学院学报》2017年第7期954-957,共4页Journal of Hainan Medical University

基　　金：湖北省科技计划项目(2015DD2139)~~

摘　　要：目的:探讨法舒地尔注射液辅助手术治疗脑外伤对应激激素及炎症因子的影响。方法:选择手术治疗的脑外伤患者120例,按照入组序列号奇偶数分为对照组与观察组各60例,其中对照组术后给予止血、控制颅内压、神经营养药物以及抗感染等常规治疗,观察组在常规治疗的基础上给予法舒地尔注射液治疗,比较两组治疗前(T0)、治疗3d(T1)、7d(T2)后血清应激激素ACTH、NE、Cor及炎症因子IL-1、IL-6、TNF-α水平。结果:两组T0血清ACTH、NE、Cor水平以及IL-1、IL-6、TNF-α水平比较差异不大(P>0.05);随着治疗的进行,两组T1、T2血清ACTH、NE及Cor水平均低于T0时,T2低于T1时,呈逐渐降低的趋势,两组T1血清IL-1、IL-6及TNF-α水平均高于T0时,T2低于T1和T0时,呈先升高后降低的趋势,差异均有统计学意义(P<0.05);观察组T1时血清ACTH、NE、Cor水平以及IL-1、IL-6、TNF-α水平均显著低于对照组T1时;观察组T2时血清ACTH、NE、Cor水平以及IL-1、IL-6、TNF-α水平均显著低于对照组T2时,差异均有统计学意义(P<0.05)。结论:法舒地尔注射液可有效减轻减轻脑外伤手术患者应激反应,控制炎症因子水平。Objective：To investigate the effect of fasudil injection on stress hormone and inflammatory factors in the treatment of traumatic brain injury.Methods：A total of 120 cases of traumatic brain injury were divided into control group and observation group according to the odd with 60 cases in each group.The control group was given conventional therapy including hemostasis,intracranial pressure control,neurotrophic drugs and anti-infection,the observation group was given fasudil injection on the basis of routine treatment,compare the serum stress hormones ACTH,NE,Cor and inflammatory factors IL-1,IL-6,TNF-αlevels between two groups before treatment（T0）and after treatment 3d（T1）and 7d（T2）.Results：The ACTH,NE,Cor and IL-1,IL-6,TNF-αlevels in T0 serum were not significantly different between the two groups（all P〉0.05）.As the treatment progressed,serum ACTH,NE,Cor levels of T1 and T2were lower than T0 in both groups,when T2 was lower than T1,which showed a gradual downward trend,two groups of T1 serum IL-1,IL-6and TNF-αlevels were higher than T0,when T2 was lower than T1 and T0,it showed increased first and then decreased,the difference was statistically significant（P〈0.05）;Observation group T1 serum ACTH,NE,Cor and IL-1,IL-6and TNF-αlevels were（67.2±9.8）pg/mL,（685.71±181.83）pg/mL,（251.65±50.35）ng/mL,（6276.38±52.05）pg/mL,（231.34±29.02）pg/mL,（92.21±15.25）ng/mL,respectively,significantly lower than those in T1 of the control group;Observation group T2 serum ACTH,NE,Cor and IL-1,IL-6and TNF-αlevels were（55.16＋8.05）pg/mL,（426.72＋150.14）pg/mL,（202.36＋39.18）ng/mL,（108.37＋38.38）pg/mL,（111.36＋21.15）pg/mL,（40.72＋13.42）ng/mL respectively,significantly lower than those in T2 of the control group,the differences were statistically significant（P〈0.05）.Conclusions：Fasudil injection can relieve the stress reaction and control the level of inflammatory factors in patients with brain trauma.

关 键 词：法舒地尔 脑外伤 应激激素 炎症因子 

分 类 号：R651.11[医药卫生—外科学]