血浆同型半胱氨酸水平与脑静脉窦血栓形成及预后的关系  

The relationship between the plasma homocysteine levels and the prognosis of cerebral venous sinus thrombosis

作　　者：贾卓鹏[1] 金林[1] 车红民[1] 

机构地区：[1]西安医学院第一附属医院神经外科,陕西西安710077

出　　处：《中华神经外科疾病研究杂志》2017年第3期225-228,共4页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的探讨血浆同型半胱氨酸水平与脑静脉窦血栓形成及预后的关系。方法检测31例脑静脉窦血栓(CVST)患者及30例健康对照组血同型半胱氨酸(Hcy)水平,将CVST患者分组为高Hcy及正常Hcy组并进行神经功能缺损评估,比较不同组之间血Hcy水平的差异及Hcy对CVST患者预后的影响。结果 (1)CVST组中Hcy显著高于对照组,而叶酸,维生素B12均显著低于对照组(P<0.01);(2)CVST患者组中高Hcy组与正常Hcy组预后比较,好转率高Hcy血症组低于正常Hcy组(P<0.05)。结论高同型半胱氨酸血症是脑静脉窦血栓形成的危险因素,伴有高同型半胱氨酸血症的CVST患者预后不佳。Objective The relationship between the plasma homocysteine levels and the prognosis of cerebral venom sinus thrombosis were discussed. Methods The blood homocysteine （Hcy） data of 31 patients with cerebral venous sinus thrombosis （CVST） and 30 cases of healthy controls were collected. These CVST patients were divided into high Hcy and normal Hcy group and the neural function defects were evaluated. The blood Hcy levels of different groups were compared, and the effect of Hcy on the prognosis of patients with CVST was analyzed. Results Hcy level in CVST group was significantly higher than that of the control group, and while the levels of folic acid and vitamin B12 were significantly lower than those of control group （P 〈0. 01） ; compared with normal Hcy group, the prognosis of high Hcy group was poorer than that of the normal Hcy group （P 〈 0. 05 ）. Conclusion High homocysteine level is a risk factor for the cerebral venom sinus thrombosis. The patients with CVST complicated by high homocysteine levels have the poor prognosis.

关 键 词：同型半胱氨酸 脑静脉窦血栓 危险因素 预后 

分 类 号：R651[医药卫生—外科学]