铬蓝K电聚合膜修饰电极检测吲哚美辛  

Electropolymerization of Acide Chrome Blue K on Glassy Carbon Electrode for Determination of Indomethacin

作　　者：梁彩云[1] 覃昀 张翠忠[1] 连欢[1] 刘宇霞[1] 

机构地区：[1]广西民族师范学院,广西高校桂西南特色植物资源化学重点实验室培育基地,广西崇左532200

出　　处：《广州化工》2017年第9期142-145,共4页GuangZhou Chemical Industry

基　　金：广西自然科学基金项目(No:2016GXNSFAA380113)

摘　　要：运用循环伏安法将酸性铬蓝K聚合在玻碳电极表面形成聚合膜制备修饰电极。运用电化学交流阻抗和循环伏安法研究吲哚美辛在酸性铬蓝K电聚合膜修饰电极上的电化学行为。经对溶液的pH和扫描速率等条件进行优化处理。在最佳实验条件下,吲哚美辛的峰电流值与其浓度在3×10^(-7)~4×10^(-5)mol/L范围内呈良好的线性关系,检出限为9.77×10^(-8)mol/L,该方法可进一步应用于吲哚美辛肠溶片和吲哚美辛胶囊吲哚美辛含量检测,回收率在99.44%~101.39%之间。Using cyclic voltammetry of acid chrome blue K polymerization in preparation of glassy carbon electrode surface to form polymer film modified electrode, the electrochemical behavior of indomethacin in polymer film modified electrode was studied by cyclic voltammetry（CV）and difference pulse voltammetry（DPV）. Parameter pH value and scan rate were optimized. Under the optimized experimental condition, the peak currents of indomethacin was linear to their concentrations at the range of 3 × 10-7 - 4× 10-5 mol/L and its detection limit was 9.77 × 10-8 mol/L. This method was applied for the detection of content of indomethacin in indomethacin enteric- coated metformin hydrochloride and indomethacin capsules samples, the recoveries were 95.64% - 102.05% , 95.46% - 106.95% , respectively.

关 键 词：酸性铬蓝K 玻碳电极 吲哚美辛 

分 类 号：O657.1[理学—分析化学]